EFEKTIVITAS ZINGIBER OFFICINALE (EKSTRAK JAHE) SEBAGAI PROFILAKSIS TAMBAHAN DALAM MENURUNKAN KEJADIAN CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING DERAJAT SEDANG-BERAT
Background: Chemotherapy-induced nausea and vomiting (CINV) remains one of the most feared side effects of chemotherapy. It negatively impacts health-related quality of life. Many antiemetic drugs have been employed for their prevention and treatment CINV, but CINV was still not fully prevented. Gin...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| Summary: | Background: Chemotherapy-induced nausea and vomiting (CINV) remains one of
the most feared side effects of chemotherapy. It negatively impacts health-related
quality of life. Many antiemetic drugs have been employed for their prevention and
treatment CINV, but CINV was still not fully prevented. Ginger has been used to
treat numerous types of nausea and vomiting and has been studied for its efficacy for
CINV.
Objective: To assess the efficacy of ginger as add-on a standard antiemetic
prophylaxis (5-HT3 RAs-ondansetron and dexamethasone) to reduce the incidence of
moderate to severe CINV
Method: This study was conducted in Tulip Cancer Clinic and Internal Medicine
wards Dr Sardjito Hospital Yogyakarta Indonesia. In this randomized, double-blind,
placebo-controlled trial, assigned 50 patients with early stage breast cancer who
received the first cycle anthracycline-based chemotherapy. Participants were
randomized into 2 arms. All patients received 8 mg 5-HT3Â receptor antagonist
injection (ondansetron) and 20 mg dexamethasone
Â
 injection on day 1 of cycle to
prevent acute CINV plus two 250 mg capsules of ginger
Â
or placebo twice daily antecoenam
as add-on for three days administered three days before
Â
the first day of cycle.
Dexamethasone 8 mg single dose orally were administered for 3 days starting the
same day after chemotherapy completed to prevent delayed CINV as standard
prophylaxis plus two 250 mg capsules of ginger
Â
or placebo twice daily ante-coenam
as add-on for five days on day 4 continuing previous administering . Outcome was
measured with National Cancer Institute�Common Toxicity Criteria Adverse Events
V4.0 (NCI CTCAE V4.0). Differences in incidences in two arms were analyzed by
the chi-square test and fisher�s exact test respectively.
Results: None of participants experienced severe CINV. Acute moderate nausea was
observed in 2/50 (4%) in ginger group as compared to 8/50 (16%) in control group
(p=0.037). Delayed moderate nausea was more in the control group compared to the
ginger group [14/50 (28%) vs 9/50 (18%) respectively (p=0.128)]. Acute and delayed
moderate vomiting was observed almost equal in the both groups [(1/50 (2%) vs 3/50
(6%) with p=0.305 |
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