| Summary: | Hypertension cause changes in the structure and function of cardial as triggers
neurohormonal and vascular changes that concentric cardiac hypertrophy. Myocyte
volume expansion or increased pressure will trigger the synthesis of pre-proBrain
Natriuretic Peptide (BNP) in the ventricular myocardium. Pre-proBNP will be
converted into proBNP and proBNP will be converted into the form of BNP and Nterminal
proBNP (NT proBNP).
This study aimed to determine differences in NT proBNP in hypertensive
patients without LVH and hypertensive patients with LVH. The study design was
cross-sectional in cardiology policlinic�s outpatient at Dr. Sardjito General Hospital
Yogyakarta from August 2009 until the sample number is fulfilled. To analyze the
difference between the two groups of hypertensive patients using the Student t test
for normal distribution, while for abnormal distribution were analyzed with the
Mann-Whitney U test. To analyze the normality of data conducted Kolmogorov-
Smirnov. The differences of two groups of hypertensive patients considered as
significant if p < 0.05 with confidence interval of 95%.
The results showed 73 study subjects grouped subjects into 2 groups:
hypertensive subjects without LVH (31 subjects) and with LVH (42 subjects) based
on echocardiography parameters (IVSD, LVPWd, LVIDd, LVM, LVMI) consisting
of 24 males and 49 women. The baseline characteristics between the study groups of
hypertensive subjects with and without LVH did not differ significantly either in age,
BMI, blood pressure, duration of hypertension. Therapeutic characteristics of the use
of drugs such as ACEI, ARB, β-blocker, CCB, spironolactone and furosemide. Mean
NT proBNP levels in hypertensive group without LVH (46.60 + 45.51) and
hypertension with LVH group (201.60 + 192.30 ng / ml). From the results of the
Kolmogorov-Smirnov test result that the data distribution is not normal so used
Mann-Whitney U test. Obtained a statistically significant difference
Conclusion. There were significant differences in the mean levels of serum
NT proBNP in hypertensive patients without LVH and hypertensive patients with
LVH.
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