PERBANDINGAN DAYA GUNA AMPISILIN INTRAVENA DAN SEFTRIAKSON INTRAVENA PADA ANAK DENGAN INFEKSI SALURAN KEMIH
Background. Urinary tract infections (UTI) is prevalent and among the main morbidity in children. Prompt diagnosis and therapy of UTI is essential to prevent complication of renal scarring. Many studies have shown high rates of resistance to ampicillin as one oftherapeutic option for UTI. This study...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| Summary: | Background. Urinary tract infections (UTI) is prevalent and among the main morbidity in children. Prompt diagnosis and therapy of UTI is essential to prevent complication of renal scarring. Many studies have shown high rates of resistance to ampicillin as one oftherapeutic option for UTI. This study was aimed to compare the efficacy of intravenousampicillin and ceftriaxone in treating children with UTI.
Method. This is a single blind clinical trial carried out in Department of Child Health, Dr. Sardjito Teaching Hospital. The subjects consisted of 112 children aged 2 month until 15 years old. The subjects were randomly allocated into ampicillin group (n = 56) and ceftriaxone (n = 56). The antibiotics were given for 3 consecutive days. The efficacy of therapy was evaluated by clinical and laboratory improvement.
Results. The efficacy for intravenous ampicillin after 3 days of treatment 64.3% and 71.4% of intravenous ceftriaxone and not statistically different. Sensitivity ampicillin and ceftriaxone are also not statistically different, respectively 44.4% and 55.6%. Based on the results of urine culture, E.coli is a bacteria most likely to cause UTI in children (24%).
Conclusion. There is no difference in efficacy between intravenous ampicillin and ceftriaxone therapy in children with UTI |
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