| Summary: | Skin wounds are common, however the duration of recovery for each
animal is different. Many factors impede the wound healing process, either comes
from within the body or outside the body, one of which is obesity. The assumption
that fat animals are always healthy is not always true, because it often ends in case
of overweight or even obese. Provision of zinc are known to accelerate the wound
healing process. Monitoring of wound healing can be done by examine the
infiltration of inflammatory cells in the wound area. This study was aimed to
determine the effect of topical zinc the number of leukocytes in skin tissue injury
of the rats given high fat diet. This study was used 32 Sprague Dawley rats which
were given high fat diet. After 2 months of treatment, the rats were incised on the
back and were given topical zinc. The skin around the wound were taken on the
first and third day post-incision for histopathological preparations the number of
leukocytes around the incision area were calculated.
The number of leucocytes was analyzed using ANOVA factorial (2x2x2),
while histopatological analysis was done descriptively. The result showed that
there was significant interaction between diet and topical zinc (P < 0,05). It was
concluded that administration of zinc in rats with high fat diet affects the number
of leukocytes in tissue injury.
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