PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR LESIONS THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON HISTOPATHOLOGICAL OF EYES INDUCED BY IN CIGARETTE SMOKE WISTAR RATS
An increasing number of smokers who tend to rise rapidly from year to year has become a major focus of public health issues. Exposure to environmental tobacco smoke, containing toxic chemicals can trigger acute or chronic inflammation and oxidative stress in the eyes. To overcome this condition, phy...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| author | , AGAPIETTA KUSUMAWARDANI , Prof. drh. R. Wasito, M.Sc., Ph.D. |
| author_facet | , AGAPIETTA KUSUMAWARDANI , Prof. drh. R. Wasito, M.Sc., Ph.D. |
| author_sort | , AGAPIETTA KUSUMAWARDANI |
| collection | UGM |
| description | An increasing number of smokers who tend to rise rapidly from year to year has
become a major focus of public health issues. Exposure to environmental tobacco smoke,
containing toxic chemicals can trigger acute or chronic inflammation and oxidative stress in
the eyes. To overcome this condition, phytotherapeutic and/or phytopreventive approaches
which are efficatious, safe and cheap is needed. One of spices from Indonesia which is
greatly possible to be promoted as a herbal medicine is a phytochemical curcumin in
turmeric. This present study was conducted to identify and determine the effects of turmeric
extract (Curcuma domestica Val.) as phytotherapeutic and/or phytopreventive in the eyes
lesion of Wistar rats induced by cigarette smokes. Twenty male Wistar rats at 3 months old
were divided randomly into four groups of five each. Those were the control group (KI), the
group given 9 cigarettes smoke/day (K II), the group given turmeric extract 1 ml 0, 25% /day
(K III) and the group given 9 cigarettes smoke/day and 0, 25% turmeric extract 1 ml /day (K
IV) for 60 days. Water and feed was given ad libitum. At the end of the experiment, all rats
were euthanized with ether, necropsied and eyes balls were collected, fixed formalin 10% and
stained with routine hematoxylin-eosin. The results of the present study indicated that 9
cigarettes smoke/day increased mitotic activity and caused hyperplasia in the corneal
epithelial cells (K II), and addition of turmeric extract 0, 25% 1 ml per oral for 60 days
prevented both mitotic activity and hyperplasia in the corneal epithelial cells (K IV). Extract
of turmeric (Curcuma domestica Val.) has been proved to have herbal therapeutic and/or
preventive effects againts the pathotoxicological cigarette smokes. Further study needs to be
done to evaluate more pathogenesis of the eyes lesions and phytotherapeutic and/or
phytopreventive effects of turmeric extract as well. |
| first_indexed | 2024-03-13T22:55:28Z |
| format | Thesis |
| id | oai:generic.eprints.org:121297 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:55:28Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1212972016-03-04T08:21:03Z https://repository.ugm.ac.id/121297/ PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR LESIONS THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON HISTOPATHOLOGICAL OF EYES INDUCED BY IN CIGARETTE SMOKE WISTAR RATS , AGAPIETTA KUSUMAWARDANI , Prof. drh. R. Wasito, M.Sc., Ph.D. ETD An increasing number of smokers who tend to rise rapidly from year to year has become a major focus of public health issues. Exposure to environmental tobacco smoke, containing toxic chemicals can trigger acute or chronic inflammation and oxidative stress in the eyes. To overcome this condition, phytotherapeutic and/or phytopreventive approaches which are efficatious, safe and cheap is needed. One of spices from Indonesia which is greatly possible to be promoted as a herbal medicine is a phytochemical curcumin in turmeric. This present study was conducted to identify and determine the effects of turmeric extract (Curcuma domestica Val.) as phytotherapeutic and/or phytopreventive in the eyes lesion of Wistar rats induced by cigarette smokes. Twenty male Wistar rats at 3 months old were divided randomly into four groups of five each. Those were the control group (KI), the group given 9 cigarettes smoke/day (K II), the group given turmeric extract 1 ml 0, 25% /day (K III) and the group given 9 cigarettes smoke/day and 0, 25% turmeric extract 1 ml /day (K IV) for 60 days. Water and feed was given ad libitum. At the end of the experiment, all rats were euthanized with ether, necropsied and eyes balls were collected, fixed formalin 10% and stained with routine hematoxylin-eosin. The results of the present study indicated that 9 cigarettes smoke/day increased mitotic activity and caused hyperplasia in the corneal epithelial cells (K II), and addition of turmeric extract 0, 25% 1 ml per oral for 60 days prevented both mitotic activity and hyperplasia in the corneal epithelial cells (K IV). Extract of turmeric (Curcuma domestica Val.) has been proved to have herbal therapeutic and/or preventive effects againts the pathotoxicological cigarette smokes. Further study needs to be done to evaluate more pathogenesis of the eyes lesions and phytotherapeutic and/or phytopreventive effects of turmeric extract as well. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , AGAPIETTA KUSUMAWARDANI and , Prof. drh. R. Wasito, M.Sc., Ph.D. (2013) PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR LESIONS THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON HISTOPATHOLOGICAL OF EYES INDUCED BY IN CIGARETTE SMOKE WISTAR RATS. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61373 |
| spellingShingle | ETD , AGAPIETTA KUSUMAWARDANI , Prof. drh. R. Wasito, M.Sc., Ph.D. PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR LESIONS THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON HISTOPATHOLOGICAL OF EYES INDUCED BY IN CIGARETTE SMOKE WISTAR RATS |
| title | PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma
domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA
YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR
LESIONS
THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON
HISTOPATHOLOGICAL OF EYES INDUCED BY
IN CIGARETTE SMOKE WISTAR RATS |
| title_full | PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma
domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA
YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR
LESIONS
THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON
HISTOPATHOLOGICAL OF EYES INDUCED BY
IN CIGARETTE SMOKE WISTAR RATS |
| title_fullStr | PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma
domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA
YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR
LESIONS
THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON
HISTOPATHOLOGICAL OF EYES INDUCED BY
IN CIGARETTE SMOKE WISTAR RATS |
| title_full_unstemmed | PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma
domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA
YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR
LESIONS
THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON
HISTOPATHOLOGICAL OF EYES INDUCED BY
IN CIGARETTE SMOKE WISTAR RATS |
| title_short | PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma
domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS MATA
YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR
LESIONS
THE EFFECT OF TURMERIC (Curcuma domestica Val.) EXTRACT ON
HISTOPATHOLOGICAL OF EYES INDUCED BY
IN CIGARETTE SMOKE WISTAR RATS |
| title_sort | pengaruh pemberian ekstrak rimpang kunyit curcuma domestica val terhadap gambaran histopatologis mata yang diinduksi asap rokok pada tikus putih wistar lesions the effect of turmeric curcuma domestica val extract on histopathological of eyes induced by in cigarette smoke wistar rats |
| topic | ETD |
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