| Summary: | This study is aimed to observe and determine the possibility of the
protective effects of turmeric extract administration toward pathotoxicologic
lesions in the trachea of Wistar rats induced by cigarette smokes acutely. Twenty
male Wistar rats at ± 3 months old were divided randomly into four groups of five
each. Group I is a control group, Group II was given 9 cigarettes/day (KII), Group
III was given by turmeric extract 0,25% 1 ml/day (K III) and Group IV was given
by 9 cigarettes/day and turmeric extract 0,25% 1 ml/hari (K IV). The present
study was conducted for 60 days. At the end of the study, all of the rats were
euthanized by ether, undergone necropsy and the tracheas were collected to be
fixed into neutral buffer formalin 10%. Tracheas were then processed
histopathologically and stained routinely with hematoxylin eosin (HE). The result
of the present study indicated that tracheas in the rats of Groups KI, KII and KIII
were normal. Whereas trachea in the rats of group KIV had histopathologic
lesions, such as diffuse hemorrhages, hyperplasia of the epithelial cells, apoptotic
body, cilia erosion and necrosis. Based on the results of the present study, it is
concluded that turmeric extract administration could prevent the occurence of
pathologic lesions in the trachea of the rats induced by cigarette smokes.
|
|---|