PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA
Introduction : Dyslipidemia is the biggest risk factor of Coronary Hearth Disease (CHD). Dyslipidemia is lipid disorders marked by increasing of total cholesterol, triglyseride, and LDL-cholesterol, and decreasing of HDL-Cholesterol in plasma. The high prevalence of Hypercholesterolemia found in pat...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: |
| _version_ | 1797033639594164224 |
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| author | , LAILA MAKNUNAH , DR. Med. dr. Indwani Astuti |
| author_facet | , LAILA MAKNUNAH , DR. Med. dr. Indwani Astuti |
| author_sort | , LAILA MAKNUNAH |
| collection | UGM |
| description | Introduction : Dyslipidemia is the biggest risk factor of Coronary Hearth Disease
(CHD). Dyslipidemia is lipid disorders marked by increasing of total cholesterol,
triglyseride, and LDL-cholesterol, and decreasing of HDL-Cholesterol in plasma.
The high prevalence of Hypercholesterolemia found in patient with CHD.
Cholesterol lowering theraphy can be done by giving Jamaican Cherry. Jamaican
Cherry contains active compound as antioxidant such as 80,5 g/100 g Jamaican
cherry of Vitamin C.
Objective : This study was performed to investigate the effect of Jamaican
Cherry Juice (Muntingia calabura) to the level of total cholesterol of mice�s
Sprague Dawley given high lipid diet, to investigate the optimal dose of Jamaican
cherry(Muntingia calabura) juice in lowering total cholesterol in plasma, and to
investigate the preventive effect of Jamaican cherry (Muntingia calabura) juice in
mice�s of Sprague Dawley in high lipid diet.
Method : Pre and Posttest with control group was used as design in this study.
Twenty five males Sprague Dawley divided into 5 groups. K1 as normal control
and K5 as sick control group. Group K2, K3, K4 as intervention group which is K4
is preventive group. Every group was adapted for 7 days got standard diet. All
group received high lipid diet for 35 days (except K5), and preventive group
received dose 2 (2,3ml/200 g BB) everyday. In 14 days intervention K2 got
1,15ml/200 g BB, K3 2,3 ml/200 g BB, K4 2,3 ml/200 g BB+high lipid diet. Their
blood plasma were taken for measure of total cholesterol on 7th day adaptation,
35th day high lipid diet, and 14th intervention.
Result : The result show that total cholesterol before and after giving Jamaican
juice significantly different (p<0,05), but not significantly different among every
group (p>0,05). The lowering of total cholesterol for each group is 15,9% (K1),
15,07% (K2), 15,305% (K3), 13,37% (K4), and 13,2% (K5).
Conclusion : Jamaican juice has the lowering effect of total cholesterol in
Dyslipidemia�s mice of Sprague Dawley. Optimal dose of lowering cholesterol
total is 2,3ml/200 g BB. This Jamaican juice can also be put in high lipid diet as
prevention of dyslipidemia which the lowering ability of total cholesterol is
13,37%. |
| first_indexed | 2024-03-13T22:57:27Z |
| format | Thesis |
| id | oai:generic.eprints.org:121802 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:57:27Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1218022016-03-04T08:39:42Z https://repository.ugm.ac.id/121802/ PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA , LAILA MAKNUNAH , DR. Med. dr. Indwani Astuti ETD Introduction : Dyslipidemia is the biggest risk factor of Coronary Hearth Disease (CHD). Dyslipidemia is lipid disorders marked by increasing of total cholesterol, triglyseride, and LDL-cholesterol, and decreasing of HDL-Cholesterol in plasma. The high prevalence of Hypercholesterolemia found in patient with CHD. Cholesterol lowering theraphy can be done by giving Jamaican Cherry. Jamaican Cherry contains active compound as antioxidant such as 80,5 g/100 g Jamaican cherry of Vitamin C. Objective : This study was performed to investigate the effect of Jamaican Cherry Juice (Muntingia calabura) to the level of total cholesterol of mice�s Sprague Dawley given high lipid diet, to investigate the optimal dose of Jamaican cherry(Muntingia calabura) juice in lowering total cholesterol in plasma, and to investigate the preventive effect of Jamaican cherry (Muntingia calabura) juice in mice�s of Sprague Dawley in high lipid diet. Method : Pre and Posttest with control group was used as design in this study. Twenty five males Sprague Dawley divided into 5 groups. K1 as normal control and K5 as sick control group. Group K2, K3, K4 as intervention group which is K4 is preventive group. Every group was adapted for 7 days got standard diet. All group received high lipid diet for 35 days (except K5), and preventive group received dose 2 (2,3ml/200 g BB) everyday. In 14 days intervention K2 got 1,15ml/200 g BB, K3 2,3 ml/200 g BB, K4 2,3 ml/200 g BB+high lipid diet. Their blood plasma were taken for measure of total cholesterol on 7th day adaptation, 35th day high lipid diet, and 14th intervention. Result : The result show that total cholesterol before and after giving Jamaican juice significantly different (p<0,05), but not significantly different among every group (p>0,05). The lowering of total cholesterol for each group is 15,9% (K1), 15,07% (K2), 15,305% (K3), 13,37% (K4), and 13,2% (K5). Conclusion : Jamaican juice has the lowering effect of total cholesterol in Dyslipidemia�s mice of Sprague Dawley. Optimal dose of lowering cholesterol total is 2,3ml/200 g BB. This Jamaican juice can also be put in high lipid diet as prevention of dyslipidemia which the lowering ability of total cholesterol is 13,37%. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , LAILA MAKNUNAH and , DR. Med. dr. Indwani Astuti (2013) PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61900 |
| spellingShingle | ETD , LAILA MAKNUNAH , DR. Med. dr. Indwani Astuti PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title | PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title_full | PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title_fullStr | PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title_full_unstemmed | PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title_short | PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA |
| title_sort | pengaruh pemberian jus buah kersen muntingia calabura terhadap kadar kolesterol total pada tikus sprague dawley dislipidemia |
| topic | ETD |
| work_keys_str_mv | AT lailamaknunah pengaruhpemberianjusbuahkersenmuntingiacalaburaterhadapkadarkolesteroltotalpadatikusspraguedawleydislipidemia AT drmeddrindwaniastuti pengaruhpemberianjusbuahkersenmuntingiacalaburaterhadapkadarkolesteroltotalpadatikusspraguedawleydislipidemia |