| Summary: | Hydroxyapatite (HA) has been used in medical field as bone graft material
since long time ago, however it has some differences with biological apatites.
Hydroxyapatite is low soluble and very stable therefore inhibits bone remodeling
rate. Carbonated hydroxyapatie is bone substitute alternative material besides
HA. Recent studies showed that CHA has similarity with biological apatite and
better osteoconductivity than HA. Biomaterial implantation always be followed by
inflammatory response, foreign-body reaction, and fibrous encapsulation. The
aim of this study was to compare quantity and quality of fibrous capsule after
subcutaneous implantation of CHA and HA in Rattus norvegicus.
Fifteen male rats (Rattus norvegicus, 3-4 months age, 200-275 gram) were
involved in this study. Left side of rat�s back was implanted with CHA, while the
right side was implanted with HA. Each 3 rats was terminated after 5, 7, 14, 21,28
implantation day to collect the implantation area for histological preparation
(Hematoxylin-Eosin staining). Quantity and quality of fibrous capsules were
evaluated by 3 observer using trinocular microscope (magnification of 400x, 6
field of view).
Results showed no significant differences on fibrous capsules quantity and
quality after CHA and HA implantation at same periods (p � 0,05). The fibrous
capsules quantity and quality of CHA and HA inter-implantation periods showed
no significant differences. The results described that CHA and HA implantation
can lead similar subcutaneous tissue responses until 28th day postimplantation.
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