| Summary: | Wound healing is the complex and dynamic process that results in the
restoration of anatomical continuity and function. Angiogenesis is formation of
new blood vessels which is one component of wound healing, can restore the
blood supply to wounded tissue. Binahong was proven as a wound healing
accelerator for it�s phytochemical properties, such as flavonoid, saponin, alkaloid,
flavonoid, and ascorbic acid. The aim of this study was to investigate the effect of
extract of binahong�s leaves on gingival wound healing process in white rats in
term of blood vessels� count.
Forty five rats were wounded by punch biopsy with diameter of 2.5 mm at
gingival mucosa above the front teeth of upper and lower jaws with a depth untill
periosteum tissues, then separated into five groups : first group was given 0%
extract (negative control), second group was given 10% extract of binahong
leaves, third group was given 20% extract of binahong leaves, fourth group was
given 40% extract of binahong leaves, and fifth group was given povidone iodine
10% (positive control). Wound tissue taken at 3rd, 5th, and 7th days and processed
into histological sample preparations with Mallory�s staining.
The result of two way ANOVA showed that there was significant effect
for treatment and the day to blood vessels� count (p<0,05). Extract of binahong
leaves concentration of 10% had the highest mean on 3rd and 5th day, while on the
7th day the highest mean was binahong 40% extract. LSD test between treatment
group with highest mean from each days and negative control showed no
significant difference (p>0,05).
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