| Summary: | Epilepsy is a chronic disease in neurology and the second most common
disease after stroke. Epilepsy cases in Indonesia is at least 700,000-1,400,000
cases with accretion of 70,000 new cases each year and estimated 40-50% of
prevalence occurred in children. Valproic acid is anti-epileptic drug that is widely
used in Indonesia especially in children. It belongs to the medicine with a narrow
therapeutic index which requires monitoring in the drug levels in plasma and dose
adjustments to prevent toxic effects. This study aims to determine the estimated
value of valproic acid concentration in serum and clinical outcomes in child
patients with epilepsy seen from seizure-free duration at RSUD Sleman
Yogyakarta.
This study was a retrospective with design descriptive observational study.
Subject in research was child patients with epilepsy who received valproic acid
therapy in the period of January 2010-December 2012 aged 1 to 18 years, boys
and girls who were routinely controlled for at least 6 consecutive months. Clinical
outcomes were observed through the duration of the seizure-free which is devided
into 2, ie <6 months (unfavorable outcome), and � 6 months (a good outcome).
The results study of 99 patients met the inclusion criteria in the group of
age less than or equal to 5 years as much as 27.28%, and 36.36% in the group of
age >5-12 years and >12-18 years. From the calculation, average estimated value
of valproic acid concentrations in serum for girls group, Css
max as much as
86,32±49,25 mg/L and Css
min 33,26±22,06 mg/L, in boys group Css
max as much as
94,91±44,72 mg/L and Css
min 38,57±20,72 mg/L. Clinical outcomes was assessed
based on the duration of seizure-free patients showed in the group with
monotherapy as much as 52,33% gave a good outcome and 47,67% gave a poor
outcome. In group with polytherapy as much as 61,54% gave a good outcome and
38,46% gave a poor outcome.
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