| Summary: | Background: Breast carcinoma metastasis particularly by
lymphatic vessel and lymphangiogenesis is the prominent
process. Lymphangiogenesis can be detected by
lymphovascular density. Uncontrolled cell carcinoma
proliferation can induce lymphangiogenesis. Correlation
between Ki-67 expression with lymphovascular density
need to advance investigated.
Aim : To study the correlation between Ki-67 expression
and lymphovascular density in ductal invasive breast
carcinoma.
Method: 39 paraffin embedded tissue of specimen
invasive ductal carcinoma of the breast were stained
immunohistocemically using Streptavidin-Biotin staining
method with monoclonal antibody anti Ki-67 and anti D2-
40. Ki-67 expression was the number of carcinoma cell
which nuclear expressed Ki-67. Lymphovascular density
was the number of peritumor lymphovascular which
endothel cell expressed antibody D2-40. The
relationship between each variables were analyzed by
chi square method.
Result: Statistical analysis showed there was no
significant correlation between Ki-67 expression and
lymphovascular density in invasive ductal carcinoma of
the breast p= 0,905 (p<0,05).
Conclusion: In this research, Ki-67 expression is not
correlated with lymphovascular density in ductal
invasive breast carcinoma.
Key: Lymphangiogenesis, Ki-67, Lymphovascular Density,
Invasive Ductal Carcinoma of the Breast.
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