PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL
Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyreticactivities. Transdermal patch delivery is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets.This study a...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| author | , EKA INDRA SETYAWAN , Dr. Akhmad Kharis Nugroho, M.Si., Apt., |
| author_facet | , EKA INDRA SETYAWAN , Dr. Akhmad Kharis Nugroho, M.Si., Apt., |
| author_sort | , EKA INDRA SETYAWAN |
| collection | UGM |
| description | Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyreticactivities. Transdermal patch delivery is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets.This study aimed to determine the effect of the combination of MC and HPMC polymers on physical properties, release and transport profileof the ketoprofen from transdermal matrix patch.
The results were analyzed using Design Expert software version 7 with simplex lattice model in order to find an optimal formula. Determination of the dissolution mechanism was analyzed using Solver based on goodness of fit between observation data and model prediction, meanwhile the transport of ketoprofen was analyzed using WinSAAM software based on compartement model.
The results provided information that a combination of MC and HPMC polymers had a significant influence on the increased the patch weight, patch thickness, loss on drying and dissolution efficiency and an insignificant effect against folding endurance. Release mechanism of ketoprofen transdermal patch following non-Fickian diffusion and an optimal formula is obtained by the combination of HPMC and MC (with ratio of 0,079:0,921) which produced the flux of ketoprofen in the range from 0.38 mg/hr up to 1.33 mg/hr, these fluxes would be expected to deliver ketoprofen with maximum plasma level (Cp max.)0.32 mg/L to 0.68 mg/L, respectively. |
| first_indexed | 2024-03-13T23:01:53Z |
| format | Thesis |
| id | oai:generic.eprints.org:122984 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:01:53Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1229842016-03-04T08:33:09Z https://repository.ugm.ac.id/122984/ PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL , EKA INDRA SETYAWAN , Dr. Akhmad Kharis Nugroho, M.Si., Apt., ETD Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyreticactivities. Transdermal patch delivery is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets.This study aimed to determine the effect of the combination of MC and HPMC polymers on physical properties, release and transport profileof the ketoprofen from transdermal matrix patch. The results were analyzed using Design Expert software version 7 with simplex lattice model in order to find an optimal formula. Determination of the dissolution mechanism was analyzed using Solver based on goodness of fit between observation data and model prediction, meanwhile the transport of ketoprofen was analyzed using WinSAAM software based on compartement model. The results provided information that a combination of MC and HPMC polymers had a significant influence on the increased the patch weight, patch thickness, loss on drying and dissolution efficiency and an insignificant effect against folding endurance. Release mechanism of ketoprofen transdermal patch following non-Fickian diffusion and an optimal formula is obtained by the combination of HPMC and MC (with ratio of 0,079:0,921) which produced the flux of ketoprofen in the range from 0.38 mg/hr up to 1.33 mg/hr, these fluxes would be expected to deliver ketoprofen with maximum plasma level (Cp max.)0.32 mg/L to 0.68 mg/L, respectively. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , EKA INDRA SETYAWAN and , Dr. Akhmad Kharis Nugroho, M.Si., Apt., (2013) PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63093 |
| spellingShingle | ETD , EKA INDRA SETYAWAN , Dr. Akhmad Kharis Nugroho, M.Si., Apt., PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title | PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title_full | PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title_fullStr | PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title_full_unstemmed | PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title_short | PENGARUH KOMBINASI POLIMER HIDROKSIPROPIL METILSELULOSA DAN METILSELULOSA TERHADAP KARAKTER FISIK, PROFIL PELEPASAN DAN TRANSPOR KETOPROFEN DARI MATRIKSPATCH TRANSDERMAL |
| title_sort | pengaruh kombinasi polimer hidroksipropil metilselulosa dan metilselulosa terhadap karakter fisik profil pelepasan dan transpor ketoprofen dari matrikspatch transdermal |
| topic | ETD |
| work_keys_str_mv | AT ekaindrasetyawan pengaruhkombinasipolimerhidroksipropilmetilselulosadanmetilselulosaterhadapkarakterfisikprofilpelepasandantransporketoprofendarimatrikspatchtransdermal AT drakhmadkharisnugrohomsiapt pengaruhkombinasipolimerhidroksipropilmetilselulosadanmetilselulosaterhadapkarakterfisikprofilpelepasandantransporketoprofendarimatrikspatchtransdermal |