| Summary: | Background. Propofol (2,6-diisopropylphenol) is commonly used for the induction and maintenance of anesthesia. Propofol is formulated in the form of emulsions with soybean oil (100 mg / ml), lecithin (12 mg / ml), and glycerol (22.5 mg / ml). Propofol formulations support the growth of bacteria. In the daily practice it�s common to use propofol up to 24 hours from the packaging (ampoules) had been opened. Therefore it is important to know that contamination of propofol out of packaging after 6 and 24 hours. The purpose of this study is to determine whether there is contamination of propofol out of packaging after storage for 6 and 24 hours.
Methods. Type of study is a prospective cohort study on 31 samples of propofol. Samples were labeled with number and checked for the color. At 0 hours, propofol was aspirated in 3 syringes each of 2 cc. The syringes then labeled the sample number, date and time (0.6 and 24 hours). They were stored in the operating room with a temperature of 20-24 ° C. Aspiration of propofol from the packaging comply with the CDC, ASA and APSF recommendation. All samples were examined for bacterial culture.
Results. Result of statistical analysis, bacterial contamination at the 6 hours was RR : 0.37 (< 1), IK 95% : 0.42 � 3.25, statistically not a risk factors. Result of statistical analysis to bacterial contamination at 24 hours was RR : 1.47 (>1), IK 95% : 1.25 � 4.14, statistically significant / is a risk factor.
Conclusion. Bacterial contamination in propofol out of packaging (ampoules) After 6 hours was RR : 0.37 (< 1), IK 95% : 0.42 � 3.25, statistically not a risk factors. While bacterial contamination in propofol out of packaging (ampoules) after 24 hours was RR : 1.47 (>1), IK 95% : 1.25 � 4.14, statistically significant / as a risk factor.
Key Words. Propofol 1%, out of packaging (ampoules), contamination
|
|---|