| Summary: | Background: extravasation is a condition of drug or fluid leakage from vein
into surrounding healthy tissue during chemotherapy regimens. Vesicants groups
of chemotherapy drugs can cause tissue necrosis. The incidence of extravasation
in chemotherapy regimens reported to be 1% to 7%. Risk factors assessed were
the following types of drugs, cannula location, age, gender, hypertension,
diabetes, number of medications, chemotherapy wards and frequency of
chemotherapy as risk factors affecting extravasation event of peripheral
intravenous chemotherapy. Extravasation is suspected when there is one or more
signs and symptoms include the following patient complained of a burning,
stinging, or pain at the puncture site, swollen, blistered at the puncture site,
redness around the area of the stabbing, there is no blood flow back and change
the quality of the drip .
Objective: to determine the incidence of extravasation and risk factors that
affect the extravasation of peripheral intravenous chemotherapy.
Methods: The design of this study was nested case control study in which
patients who received intravenous chemotherapy peripheral selected as cases and
controls without extravasation then compared with existing risk factors.
Results: event of chemotherapy extravasation as much as 12.7%.
Multivariate analysis showed that the risk factors affecting the incidence of
peripheral intravenous chemotherapy extravasation is the location of
chemotherapy and chemotherapy wards. Power of risk factors on the incidence of
chemotherapy extravasation from the smallest to the largest is the location of
chemotherapy (p <0,000, OR = 2,365, 95% CI 1,55-3,63), and chemotherapy
wards (p <0,000, OR = 3,948, CI 95% 2,12 -7,35).
Conclusion: risk factors affecting event of peripheral intravenous
chemotherapy extravasation are the location of chemotherapy and chemotherapy
wards.
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