PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK (KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS FAKTOR-α, EKSPRESI OSTEOPONTIN DAN ALKALIN FOSFATASE)
Orthodontic procedure may cause teeth movement. This study tries to find solutions in order during dental care, to minimize incident of inflammation, tissue damage and necrosis, and also induce rapid bone remodeling process and minimize relapse after active dental treatment after giving fish oil ext...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| author | , Puji Hartono , Prof. Dr. drg. Hj. Pinandi Sri Pudyani SU, Sp. Ort (K). |
| author_facet | , Puji Hartono , Prof. Dr. drg. Hj. Pinandi Sri Pudyani SU, Sp. Ort (K). |
| author_sort | , Puji Hartono |
| collection | UGM |
| description | Orthodontic procedure may cause teeth movement. This study tries to
find solutions in order during dental care, to minimize incident of
inflammation, tissue damage and necrosis, and also induce rapid
bone remodeling process and minimize relapse after active dental treatment
after giving fish oil extracted from lemuru fish (Sardinella longiceps).
Relapse is a process in which the teeth arrangement return into
condition before treatment. Lemuru fish oil contains high EPA and DHA that
may help bone remodeling by inhibiting activity of cytokine
inflammatory, accelerate bone resorption process and bone replenishment.
The purpose of this research was to investigate the effect of lemuru fish oil
administration to IL (interleukin)-1, TNF (tumor necrosis factor)-α levels,
expression of OPN (osteopontin) and ALP (alkaline phosphatase) in rabbit
alveolar bone remodeling process after being treated orthodontically.
The subjects were New Zealand White rabbit. Sample were divided into 5
groups, namely: group 1 as control group which received no fish oil or
orthodontic treatment, group 2 received no fish oil but with orthodontic treatment,
group 3, 4 and 5 were given fish oil doses 0.375, 0.75 and 1.50 g/kg body weight.
Fish oil was administered from the first day of open coil spring mounted activated
for 14 days plus the number of days of observation to-1, 3, 7 and 10 days. Blood
sampling procedure was continued until the 17thday.
The results indicated that the greatest distance interincisors in group 4 or
smallest relapse. The mean number of osteoclasts did not change after the release
of an orthodontic appliance for 4 weeks. Highest average number of osteoblasts in
group 5. The highest levels of IL-1α in group 2 and the lowest in group 5. TNF-α
levels was found lowest in group 1 but not significant different with groups 4
and 5. Osteopontin expression on day on day 1 to day 17 was found significantly
different in all treatment groups (p = 0.000). OPN levels are highest in group 2
and lowest in group 1. Alkaline phosphatase activity on day 1 to day 17 was found
significantly different in all treatment groups. Lemuru oil at a dose of 0.75 g/kg
and 1.5 g/kg body weight can increase levels of ALP after 7 days.
In conclusion, administration of lemuru fish oil induce rapid remodeling
process of alveolar bone of teeth. In addition, the lemuru fish oil reduce dental
relapse after being treated orthodontically. Moreover, this fish oil able to reduce
the number and activity of osteoclasts but stimulates the number and activity of
osteoblasts, thus in turn increases bone formation. The level and activity of IL-1α
and TNF-α can be reduce, but the expression of OPN and ALP activity can be
enhanced. |
| first_indexed | 2024-03-13T23:04:43Z |
| format | Thesis |
| id | oai:generic.eprints.org:123762 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:04:43Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1237622016-03-04T08:41:57Z https://repository.ugm.ac.id/123762/ PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK (KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS FAKTOR-α, EKSPRESI OSTEOPONTIN DAN ALKALIN FOSFATASE) , Puji Hartono , Prof. Dr. drg. Hj. Pinandi Sri Pudyani SU, Sp. Ort (K). ETD Orthodontic procedure may cause teeth movement. This study tries to find solutions in order during dental care, to minimize incident of inflammation, tissue damage and necrosis, and also induce rapid bone remodeling process and minimize relapse after active dental treatment after giving fish oil extracted from lemuru fish (Sardinella longiceps). Relapse is a process in which the teeth arrangement return into condition before treatment. Lemuru fish oil contains high EPA and DHA that may help bone remodeling by inhibiting activity of cytokine inflammatory, accelerate bone resorption process and bone replenishment. The purpose of this research was to investigate the effect of lemuru fish oil administration to IL (interleukin)-1, TNF (tumor necrosis factor)-α levels, expression of OPN (osteopontin) and ALP (alkaline phosphatase) in rabbit alveolar bone remodeling process after being treated orthodontically. The subjects were New Zealand White rabbit. Sample were divided into 5 groups, namely: group 1 as control group which received no fish oil or orthodontic treatment, group 2 received no fish oil but with orthodontic treatment, group 3, 4 and 5 were given fish oil doses 0.375, 0.75 and 1.50 g/kg body weight. Fish oil was administered from the first day of open coil spring mounted activated for 14 days plus the number of days of observation to-1, 3, 7 and 10 days. Blood sampling procedure was continued until the 17thday. The results indicated that the greatest distance interincisors in group 4 or smallest relapse. The mean number of osteoclasts did not change after the release of an orthodontic appliance for 4 weeks. Highest average number of osteoblasts in group 5. The highest levels of IL-1α in group 2 and the lowest in group 5. TNF-α levels was found lowest in group 1 but not significant different with groups 4 and 5. Osteopontin expression on day on day 1 to day 17 was found significantly different in all treatment groups (p = 0.000). OPN levels are highest in group 2 and lowest in group 1. Alkaline phosphatase activity on day 1 to day 17 was found significantly different in all treatment groups. Lemuru oil at a dose of 0.75 g/kg and 1.5 g/kg body weight can increase levels of ALP after 7 days. In conclusion, administration of lemuru fish oil induce rapid remodeling process of alveolar bone of teeth. In addition, the lemuru fish oil reduce dental relapse after being treated orthodontically. Moreover, this fish oil able to reduce the number and activity of osteoclasts but stimulates the number and activity of osteoblasts, thus in turn increases bone formation. The level and activity of IL-1α and TNF-α can be reduce, but the expression of OPN and ALP activity can be enhanced. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , Puji Hartono and , Prof. Dr. drg. Hj. Pinandi Sri Pudyani SU, Sp. Ort (K). (2013) PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK (KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS FAKTOR-α, EKSPRESI OSTEOPONTIN DAN ALKALIN FOSFATASE). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63876 |
| spellingShingle | ETD , Puji Hartono , Prof. Dr. drg. Hj. Pinandi Sri Pudyani SU, Sp. Ort (K). PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK (KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS FAKTOR-α, EKSPRESI OSTEOPONTIN DAN ALKALIN FOSFATASE) |
| title | PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK
(KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS
FAKTOR-α, EKSPRESI OSTEOPONTIN DAN
ALKALIN FOSFATASE) |
| title_full | PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK
(KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS
FAKTOR-α, EKSPRESI OSTEOPONTIN DAN
ALKALIN FOSFATASE) |
| title_fullStr | PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK
(KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS
FAKTOR-α, EKSPRESI OSTEOPONTIN DAN
ALKALIN FOSFATASE) |
| title_full_unstemmed | PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK
(KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS
FAKTOR-α, EKSPRESI OSTEOPONTIN DAN
ALKALIN FOSFATASE) |
| title_short | PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella longiceps) PADA PROSES REMODELING ALVEOLARIS GIGI KELINCI NEW ZEALAND WHITE YANG DIGERAKKAN SECARA ORTODONTIK
(KAJIAN PADA INTERLEUKIN-1, TUMOR NEKROSIS
FAKTOR-α, EKSPRESI OSTEOPONTIN DAN
ALKALIN FOSFATASE) |
| title_sort | pengaruh pemberian minyak ikan lemuru sardinella longiceps pada proses remodeling alveolaris gigi kelinci new zealand white yang digerakkan secara ortodontik kajian pada interleukin 1 tumor nekrosis faktor i ekspresi osteopontin dan alkalin fosfatase |
| topic | ETD |
| work_keys_str_mv | AT pujihartono pengaruhpemberianminyakikanlemurusardinellalongicepspadaprosesremodelingalveolarisgigikelincinewzealandwhiteyangdigerakkansecaraortodontikkajianpadainterleukin1tumornekrosisfaktoriekspresiosteopontindanalkalinfosfatase AT profdrdrghjpinandisripudyanisusportk pengaruhpemberianminyakikanlemurusardinellalongicepspadaprosesremodelingalveolarisgigikelincinewzealandwhiteyangdigerakkansecaraortodontikkajianpadainterleukin1tumornekrosisfaktoriekspresiosteopontindanalkalinfosfatase |