| Summary: | Disturbance of glucose metabolism in insulin resistance conditions can
develop into disorders of fat metabolism called dyslipidemia. Dyslipidemia
characterized by high triglycerides, low HDL and increased LDL levels, although the
increase was not significant. Andrographis paniculata (Burm.F.) Nees herbs and
curcuminoids fractions of Curcuma xanthorrhiza Roxb. rhizome have been shown to
have antihyperglycemic effects and hypercholesterolemia. Therefore, this study
aimed to determine the effect of combination of curcuminoids fractions C.
xanhorrhiza rhizome (FKRT) and n-hexane insoluble fraction of ethanolic extract of
A. paniculata herbs (FTLHEEHS) on HDL and LDL levels of male Wistar rats fed
fructose and high-fat diet.
In this study used 36 male Wistar rats treated with a high-fat diet induced and
fructose 180 mg/100 g BW orally once a day. Test animals were divided into 6
groups: normal control distilled water, negative control, FKRT 45 mg/200 g BW,
FTLHEEHS 58.55 mg/200 g BW, combined FTLHEEHS 58.55 mg/200 g BWFKRT
45 mg/200 g BW, and a positive control metformin 9 mg/200 g BW. Test
preparation was given for 25 days by providing a high-fat diet and fructose. High fat
diet was given by ad libitum, while fructose was given orally. HDL and LDL levels
in the blood were measured on days 0, 35, and 60.
Analysis of changes in blood levels of HDL and LDL levels is done by
comparing before and after the test preparation. Results of paired t-test (HDL) and
Wilcoxon (LDL) did not show any significant difference between before and after the
test preparation with P values> 0.05. Analysis of % change in HDL levels day 35 to
day 60 showed a significant difference between the negative control group with other
groups, tested with one-way ANOVA followed by Post Hoc Test.
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