| Summary: | Medicine with a narrow therapeutic range requires accurate individual
dose, monitoring, and rigorous assessment of the patient to maintain the safety
and the goodness of the patient. It is because small changes in systemic
concentrations can cause significant changes in the pharmacodynamic response,
such as subtherapeutic or toxic. Phenytoin is a medicine belonging to the class of
narrow therapy range that is widely used in patients with epilepsy. Phenytoin
complies non-linear pharmacokinetics with a slight change in dosage, it can easily
reach the toxic concentrations. This study aims to determine the relationship
between dose and phenytoin levels in the blood and outcome clinic in the patients
with epilepsy seen from the duration of seizure-free at the Local Hospital of
Sleman Yogyakarta.
This study was a descriptive observational study. The sampling method
used purposive sampling. The data was collected retrospectively on epilepsy
patients with the phenytoin treatment both inpatient and outpatient in the period of
January 2010-December 2012, male and female who were routinely controlled for
at least 6 consecutive months. Outcome clinic was observed through the duration
of the seizure-free and devided into 2, ie < 6 months (unfavorable outcome), and
� 6 months (a good outcome).
Seen by sex, male have a greater percentage than female (53,6%: 46,4%).
Estimated blood levels of phenytoin in the average 5,30±4,03 mg/L. Results
therapy are assessed based on the duration of seizure free showed that in the
group of patients who received monotherapy as much as 71,83% gives good
results, and 28,17% did not give good therapeutic results. While in the group of
patients with a 50% combination therapy provides better therapeutic results and
50% gave no good therapeutic results.
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