STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80
The controlled release of curcumin from calcium alginate (Ca-Alg) films that emulsified using Tween-80 and Span-80 had been studied. This research provides an important insight into the effect of hydrophilicity and lipophilicity of the emulsifiers on the release rates of the curcumin from Ca-Alg fil...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: |
| _version_ | 1826047341929431040 |
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| author | , TRI SEPTIANI , Dr. Dwi Siswanta, M. Eng. |
| author_facet | , TRI SEPTIANI , Dr. Dwi Siswanta, M. Eng. |
| author_sort | , TRI SEPTIANI |
| collection | UGM |
| description | The controlled release of curcumin from calcium alginate (Ca-Alg) films
that emulsified using Tween-80 and Span-80 had been studied. This research
provides an important insight into the effect of hydrophilicity and lipophilicity of
the emulsifiers on the release rates of the curcumin from Ca-Alg films.
Curcumin-loaded alginate films, which contained different ratio of
emulsifiers compositions, have been prepared using calcium chloride (CaCl2) as
the cross-linking agent. The films were characterized using Spectrometer IR and
SEM (Scanning Electron Microscopy). In vitro controlled release rate study of the
curcumin from the films were investigated for 8 hours. Hydrophile-Lipophile
Balance (HLB) value of emulsifier Tween-80 and Span 80 was varied in the range
of 11,9 to 14,0. The concentration of curcumin that released from the films at
various time intervals was determined UV-Vis Spectrophotometrically.
IR Spectrometry of Ca-Alg/kurkumin/emulsifier film characterization
showed absorption bands at 3448 cm
-1
(hydroxyl groups), 1627 cm
-1
(carbonyl
groups) of the alginate, 2924 and 2862 cm
-1
(C�H sp
3
groups of the emulsifier).
The result of SEM indicated that the microstructure of the film surface could vary
with the concentration of Tween-80 and Span-80. Films for higher concentration
of Tween-80 showed rougher surface, but films for higher concentration of Span80
were more compact. Experiment on the release of curcumin showed that the
relative amount of curcumin released within 8 hours increased from 17.7% to
64.4% when the film composition was varied from alginate:Tween-80:Span-80=
74:19:7wt% to 54:41:5wt%. The pharmacokinetics model showed that the
curcumin release from the alginate film followed Korsmeyer-Peppas equation.
This result indicated that the release mechanism was mainly by diffusion process. |
| first_indexed | 2024-03-13T23:08:58Z |
| format | Thesis |
| id | oai:generic.eprints.org:125021 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:08:58Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1250212016-03-04T08:43:56Z https://repository.ugm.ac.id/125021/ STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 , TRI SEPTIANI , Dr. Dwi Siswanta, M. Eng. ETD The controlled release of curcumin from calcium alginate (Ca-Alg) films that emulsified using Tween-80 and Span-80 had been studied. This research provides an important insight into the effect of hydrophilicity and lipophilicity of the emulsifiers on the release rates of the curcumin from Ca-Alg films. Curcumin-loaded alginate films, which contained different ratio of emulsifiers compositions, have been prepared using calcium chloride (CaCl2) as the cross-linking agent. The films were characterized using Spectrometer IR and SEM (Scanning Electron Microscopy). In vitro controlled release rate study of the curcumin from the films were investigated for 8 hours. Hydrophile-Lipophile Balance (HLB) value of emulsifier Tween-80 and Span 80 was varied in the range of 11,9 to 14,0. The concentration of curcumin that released from the films at various time intervals was determined UV-Vis Spectrophotometrically. IR Spectrometry of Ca-Alg/kurkumin/emulsifier film characterization showed absorption bands at 3448 cm -1 (hydroxyl groups), 1627 cm -1 (carbonyl groups) of the alginate, 2924 and 2862 cm -1 (C�H sp 3 groups of the emulsifier). The result of SEM indicated that the microstructure of the film surface could vary with the concentration of Tween-80 and Span-80. Films for higher concentration of Tween-80 showed rougher surface, but films for higher concentration of Span80 were more compact. Experiment on the release of curcumin showed that the relative amount of curcumin released within 8 hours increased from 17.7% to 64.4% when the film composition was varied from alginate:Tween-80:Span-80= 74:19:7wt% to 54:41:5wt%. The pharmacokinetics model showed that the curcumin release from the alginate film followed Korsmeyer-Peppas equation. This result indicated that the release mechanism was mainly by diffusion process. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , TRI SEPTIANI and , Dr. Dwi Siswanta, M. Eng. (2013) STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=65186 |
| spellingShingle | ETD , TRI SEPTIANI , Dr. Dwi Siswanta, M. Eng. STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title | STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title_full | STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title_fullStr | STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title_full_unstemmed | STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title_short | STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80 |
| title_sort | studi pelepasan in vitro kurkumin dari film kalsium alginat dengan penambahan emulsifier tween 80 dan span 80 |
| topic | ETD |
| work_keys_str_mv | AT triseptiani studipelepasaninvitrokurkumindarifilmkalsiumalginatdenganpenambahanemulsifiertween80danspan80 AT drdwisiswantameng studipelepasaninvitrokurkumindarifilmkalsiumalginatdenganpenambahanemulsifiertween80danspan80 |