| Тойм: | Background. Tubectomy is a gynecologic procedure that is often used. Total intravenous
anesthesia (TIVA) can be provided using a combination of opioid and benzodiazepine.
Postoperative nausea and vomiting (PONV) is one of the common complains following
this anesthesia procedure and can results in decrease of patient�s satisfaction and delay in
hospital discharge, especially since this is a one day surgery. Dexamethasone and
ondansetron can be used as prophylactic antiemetic drugs.
Objective.To compare the antiemetic prophylactic effect of 10 mg intravenous
dexamethasone and of 4 mg intravenous ondansetron in tubectomy with total intravenous
anesthesia (TIVA) using intravenous meperidine 2 mg/kg BW and diazepam 0,2 mg/kg
BW.
Methods. A prospective, randomized double blind controlled trial study was performed
in 96 patients with physical status according to ASA classification class I and II
underwent general anesthesia with TIVA using meperidine 2 mg/kg BW. Patients was
randomly allocated into two groups, in which group 1 was receiveddexamethasone 10 mg
intravenously and group 2wasreceivedondansetron 4 mg intravenously. The scores of
nausea and vomituswas calculated and analyzed statistically using Chi-square test. P
value of < 0,05 means statistically different.
Results.The incidence of PONV in 10 mg intravenous dexamethason group and 4 mg
intravenous ondansetron group had no significance different (p>0,05). Statistically, both
groups had same advantages and disadvantages to diminished incidence of PONV. 10 mg
10 mg intravenous dexamethasone group had lesser patients suffered from PONV (7 of
48 patients) than 4 mg intravenous ondansetron group (10 of 48 patients). All of the
patients in dexamethason group suffered PONVrepeatedly but only 6 of 10 patients in
ondansetron group experienced it and the remaining just once.
Conclusion.10 mg intravenousdexamethasone prophylactic was as same effective as 4
mg intravenous ondansetron prophylactic for prevention of PONV in tubectomy used
TIVA with meperidine 2 mg/kgBW and diazepam 0,2 mg/kgBW.
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