| Sumario: | Yellow wood (Arcangelisia flava (L.) Merr.) is one of the Indonesia plant.
Active compounds called berberin chloride can be found in this plant. This research
was conducted to find out whether the extract of water-soluble yellow wood capable
of influencing the activity of macrophage phagocytosis (the non-specific immune
response), as well as what is the concentration of chloride in the extract of berberin
arthritis activity of macrophage phagocytosis.
Water soluble extract of yellow wood is divided into three test groups. Group
I is the Group's treatment of water soluble extract of yellow wood levels of 1 mg/mL,
group II with levels of 5 mg/mL, and group III with levels of 10 mg/mL, and there is
a control group media. The macrophage cells taken from mouse peritoneal fluid strain
Wistar were used to test the macrophage phagocytosis. Results of the index and the
ratio of phagocytosis macrophages were evaluated with statistical tests with one-way
ANOVA, 95% confidence level. The qualitative and quantitative were analyzed by
Thin-Layer Chromatography (TLC).
Results of the statistical analysis shows that the ratio parameters and index
phagocytosis macrophages, just a test group III has significantly to media control,
treatment groups I and II. While the result of the qualitative analysis of active
compounds from water soluble extract of yellow wood suggests that the predominant
compounds contained in the extract is berberine chloride. Thus, it can be concluded
that the extract of water-soluble yellow wood (Arcangelisia flava (L.) Merr.) levels of
10 mg/mL have compounds berberine chloride of 0.14% (w/v) which affect the
activity of phagocytosis macrophages.
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