| Summary: | Diclofenac sodium is a Non- Steroidal Anti- inflammatory Drugs ( NSAID )
commonly used as a drug for rheumatoid arthritis or diseases commonly called
rheumatism (rheumatic) as a pain reliever. The drug is expected to have a rapid onset.
In addition, these rheumatic diseases common in geriatrics . For that, an easy way of
consumption in this preparation is needed. Drug dosage form of diclofenac sodium
with fast disintegrating tablet (FDT) is expected to reduce the existing problems, for
the optimization of diclofenac sodium FDT formula required.
Formula used for optimization with a combination of two variations
superdisintegrant, Ac-Di- Sol® and SSG, ie F1 (0:8 mg), F2 (2:6 mg), F3 (4:4 mg), F4
(6:2 mg), dam F5 (8:0 mg). Making tablets using direct clamp method. The data
obtained from testing the physical properties of tablets prepared with the program
Design Expert® version 8.0.7.1. the method of simplex lattice design.
The results obtained showed that the combination of the two superdisintegrant
that produce optimum physical properties requires a combination of 5,104 mg of Ac -
Di - Sol ® and 2.896 mg of SSG on tablets with a weight of 150 mg . This formula
produces tablets with physical properties fragility response of 0.58 %
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