| Summary: | Background: Physical exercise or sports are very
popular all over the world. However, many people ignore
the intensity of exercise performed. Too much exercise
is allegedto give an adverse effect on the heart muscle
related to increased expression of cyclooxygenase-2
(COX-2). COX-2 is a mediator of inflammation which
correlates with poor prognosis. Therefore, it is
necessary to elaborate more about the effects of
physical exercise on the expression of COX-2 in the
heart muscle.
Objective: The study was conducted to assess the effect
of physical exercise on the expression of COX-2 in the
heart muscle.
Methods: The subjects of this study were female rats
(Rattus norvegicus) strain Sprague-Dawley which were
divided into groups of mild intensity (A), moderate
intensity (B), heavy intensity (C), and a control
group. Immunohistochemical assay was used to measure
the expression of COX-2 in rat heart muscle cells.
Results:In 16 rats which were divided into 3 exercise
groups and 1 control group, the expression of COX-2 had
a tendency to increase alongside with increasing
exercise intensity. The average of COX-2 expression in
rat heart muscle for each group was significantly
different (mild: 0,62 ± 0,17
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