| Summary: | Background: Nasopharyngeal cancer (NPC) is the most common
head and neck malignancy found in Indonesia. Epstein-Barr
Virus is associated with NPC. Screening method have been
developed by detecting antibody against EBV in high risk
groups such as healthy people with high level of IgA-EBV
titer and first degree family of NPC patients.
Objectives: To compare the distribution of IgA-EBV titer in
non-family healthy individuals and first degree family of
NPC patients.
Method: Blood samples and demographic data were taken from
PMI healthy blood donors. Serum was analyzed using indirect
ELISA method to determine IgA EBV titer. Distribution of IgA
EBV titer was analyzed according to sex, age, education
level and was compared to first degree family of NPC
patients (secondary data).
Result: Seventy nine point nine percent of healthy nonfamily
individuals and 58,3% of first degree families had
IgA EBV titer below 0,350. There was significant difference
in the distribution of IgA EBV titer between healthy nonfamily
individuals and first degree families (p<0,001). The
distribution of IgA EBV titer in healthy non-family
individuals was different significantly between male and
female (p=0,008). However, in first degree families, the distribution of IgA EBV level was not significantly
different among sexes (p=0,693), groups of age (p=0,298),
and education levels (p=0,409). Furthermore, the correlation
between family history of NPC and the distribution of IgA
EBV titer was observed in male (p<0,001), less than 40 years
old individuals (p<0,001), and individuals who have lower
education level than high school (p<0,001).
Conclusion: The distribution of IgA EBV titer was different
between healthy non-family individuals and first degree
families of NPC patients. The difference was observed in
male, less than 40 years old individuals, and individuals
who have lower education level than high school.
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