PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT
Background: Rheumatoid arthritis is a degenerative joint disease that involves chronic inflammation of the joints. Drugs of choice to treat rheumatoid arthritis are Non-steroidal Anti-inflammatory Drugs (NSAID) and Disease Modifying Drugs Rheumatoid Arthritis (DMARD). The drugs turned out to have ma...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: |
| _version_ | 1826047898243039232 |
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| author | , AFIF DANI MARUFAH , dr.Setyo Purwono, M.Kes., Sp.PD |
| author_facet | , AFIF DANI MARUFAH , dr.Setyo Purwono, M.Kes., Sp.PD |
| author_sort | , AFIF DANI MARUFAH |
| collection | UGM |
| description | Background: Rheumatoid arthritis is a degenerative joint disease
that involves chronic inflammation of the joints. Drugs of choice
to treat rheumatoid arthritis are Non-steroidal Anti-inflammatory
Drugs (NSAID) and Disease Modifying Drugs Rheumatoid Arthritis
(DMARD). The drugs turned out to have many dangerous side effects.
Kitolod plant is a plant known as a medicinal plant. Which the
leaves contain alkaloids, flavonoids and saponins believed to have
anti-inflammatory effects.
Purpose: to determine the anti-inflammatory effects of ethanol
extract of kitolod leaves in female rat induced by Complete
Freund's Adjuvant (CFA).
Methods: This research was a quasi experimental. Thirty female
Wistar rats aged 2-3 months with a mean weight of 200 g were
divided into 5 treatment groups: distilled water (negative
control), methotreksat 0.2 mg / week (positive control), ethanol
extract of kitolod leaves 2.02 mg / 200 gr BW, 4.04 mg/200 gr BW,
and 8.08 mg/200 gr BW. Female rat injected with CFA 0.1 ml
subcutaneously in the left foot to cause rheumatoid arthritis �
like edema. Edema volume measurements were performed every three
days for six days. On day 6, all were began to receive treatment
in accordance with as much as 3 ml per day orally using a sonde,
unless methotreksat, given once a week. Treatment is given for 12
days to edema volume measurenment.
Results: After 3 days of treatment, the treatment group given
methotrexate 0,2 mg / week and ethano extracts of kitolod leaves
8,08 / 200 g BW showed a slight decrease in edema volume compared
to the pre-treated, but there is no significant differences
(p=0,095). After six day of treatment, no edema voume decreased in
all groups. After 12 days of treatment there were aso no reduction
in the volume of edema.
: Conclusion ethanol extract of kitolod leaves 2.02mg/200 g BW, 4,04
mg/200 g BW gives the percentage volume of smaller edema (190.87%
and 172,60%) than in distilled water (214,18%) for 12 days of
treatment in reducing chronic inflammatory edema volume of white
rat foot as complete Freund's adjuvant (CFA) induced rheumatoid
arthritis model. |
| first_indexed | 2024-03-13T23:18:26Z |
| format | Thesis |
| id | oai:generic.eprints.org:127795 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:18:26Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1277952016-03-04T07:51:40Z https://repository.ugm.ac.id/127795/ PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT , AFIF DANI MARUFAH , dr.Setyo Purwono, M.Kes., Sp.PD ETD Background: Rheumatoid arthritis is a degenerative joint disease that involves chronic inflammation of the joints. Drugs of choice to treat rheumatoid arthritis are Non-steroidal Anti-inflammatory Drugs (NSAID) and Disease Modifying Drugs Rheumatoid Arthritis (DMARD). The drugs turned out to have many dangerous side effects. Kitolod plant is a plant known as a medicinal plant. Which the leaves contain alkaloids, flavonoids and saponins believed to have anti-inflammatory effects. Purpose: to determine the anti-inflammatory effects of ethanol extract of kitolod leaves in female rat induced by Complete Freund's Adjuvant (CFA). Methods: This research was a quasi experimental. Thirty female Wistar rats aged 2-3 months with a mean weight of 200 g were divided into 5 treatment groups: distilled water (negative control), methotreksat 0.2 mg / week (positive control), ethanol extract of kitolod leaves 2.02 mg / 200 gr BW, 4.04 mg/200 gr BW, and 8.08 mg/200 gr BW. Female rat injected with CFA 0.1 ml subcutaneously in the left foot to cause rheumatoid arthritis � like edema. Edema volume measurements were performed every three days for six days. On day 6, all were began to receive treatment in accordance with as much as 3 ml per day orally using a sonde, unless methotreksat, given once a week. Treatment is given for 12 days to edema volume measurenment. Results: After 3 days of treatment, the treatment group given methotrexate 0,2 mg / week and ethano extracts of kitolod leaves 8,08 / 200 g BW showed a slight decrease in edema volume compared to the pre-treated, but there is no significant differences (p=0,095). After six day of treatment, no edema voume decreased in all groups. After 12 days of treatment there were aso no reduction in the volume of edema. : Conclusion ethanol extract of kitolod leaves 2.02mg/200 g BW, 4,04 mg/200 g BW gives the percentage volume of smaller edema (190.87% and 172,60%) than in distilled water (214,18%) for 12 days of treatment in reducing chronic inflammatory edema volume of white rat foot as complete Freund's adjuvant (CFA) induced rheumatoid arthritis model. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , AFIF DANI MARUFAH and , dr.Setyo Purwono, M.Kes., Sp.PD (2014) PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68080 |
| spellingShingle | ETD , AFIF DANI MARUFAH , dr.Setyo Purwono, M.Kes., Sp.PD PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title | PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title_full | PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title_fullStr | PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title_full_unstemmed | PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title_short | PENGARUH EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora) TERHADAP VOLUME EDEMA INFLAMASI KRONIS KAKI TIKUS PUTIH MODEL ARTRITIS REUMATOID YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT |
| title_sort | pengaruh ekstrak etanol daun kitolod isotoma longiflora terhadap volume edema inflamasi kronis kaki tikus putih model artritis reumatoid yang diinduksi dengan complete freunda��s adjuvant |
| topic | ETD |
| work_keys_str_mv | AT afifdanimarufah pengaruhekstraketanoldaunkitolodisotomalongifloraterhadapvolumeedemainflamasikroniskakitikusputihmodelartritisreumatoidyangdiinduksidengancompletefreundasadjuvant AT drsetyopurwonomkessppd pengaruhekstraketanoldaunkitolodisotomalongifloraterhadapvolumeedemainflamasikroniskakitikusputihmodelartritisreumatoidyangdiinduksidengancompletefreundasadjuvant |