| Summary: | Background : Lymphovascular Density (LVD) is a
significant indicator of lymphangiogenesis process and
it has important role in cancer metastatic. TAMs are
activated macrophages which induce angiogenesis,tumor
invasion and migration. In breast carcinoma, the
protumoral characters of TAMs is more dominant than the
antitumoral ones. The correlation between the number of
TAMs and LVD in breast carcinoma is still unclear.
Aim: To know the correlation between the number of TAMs
with LVD in breast carcinoma.
Methods : 44 samples of invasive ductal carcinoma of
the breast from Sardjito Hospital 2009 were observed in
this study. These samples were stained
immunohistochemically by anti CD-68 and anti D2-40
monoclonal antibody. Number of TAMs were determined by
counting the number of macrophages which expressed CD68
within 5 hot spot areas. Number of LVD was
determined by counting the number of lymphatic vessel
which it�s endothelial cells expressed D2-40 within 5
hot spot areas. TAMs and LVD were grouped into high and
low based on median value as cut-off. Correlation
between the number of TAMs and LVD will be analyzed
using
Pearson Chi-Square Test
correlation.
Results:
cut-off
point of TAMs was 49. Frequency of
high TAMs: 50%, low: 50%. Frequency of samples with
high LVD: 54,5%, low: 45,5%. There was no significant
correlation between TAMs and LVD in breast
carcinoma.(p=0,545),CI
95%
(0,439 � 4,757).
Conclusions : In this study TAMs have not play a
significant role in lymphovascular density in breast
carcinoma.
|
|---|