HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR PADA KARSINOMA PAYUDARA
Background : Lymphovascular Density (LVD) is a significant indicator of lymphangiogenesis process and it has important role in cancer metastatic. TAMs are activated macrophages which induce angiogenesis,tumor invasion and migration. In breast carcinoma, the protumoral characters of TAMs is more domi...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: |
| _version_ | 1797034853450907648 |
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| author | , FERDINANDUS BAYU SATRIA , dr. Irianiwati,Sp.PA(K), |
| author_facet | , FERDINANDUS BAYU SATRIA , dr. Irianiwati,Sp.PA(K), |
| author_sort | , FERDINANDUS BAYU SATRIA |
| collection | UGM |
| description | Background : Lymphovascular Density (LVD) is a
significant indicator of lymphangiogenesis process and
it has important role in cancer metastatic. TAMs are
activated macrophages which induce angiogenesis,tumor
invasion and migration. In breast carcinoma, the
protumoral characters of TAMs is more dominant than the
antitumoral ones. The correlation between the number of
TAMs and LVD in breast carcinoma is still unclear.
Aim: To know the correlation between the number of TAMs
with LVD in breast carcinoma.
Methods : 44 samples of invasive ductal carcinoma of
the breast from Sardjito Hospital 2009 were observed in
this study. These samples were stained
immunohistochemically by anti CD-68 and anti D2-40
monoclonal antibody. Number of TAMs were determined by
counting the number of macrophages which expressed CD68
within 5 hot spot areas. Number of LVD was
determined by counting the number of lymphatic vessel
which it�s endothelial cells expressed D2-40 within 5
hot spot areas. TAMs and LVD were grouped into high and
low based on median value as cut-off. Correlation
between the number of TAMs and LVD will be analyzed
using
Pearson Chi-Square Test
correlation.
Results:
cut-off
point of TAMs was 49. Frequency of
high TAMs: 50%, low: 50%. Frequency of samples with
high LVD: 54,5%, low: 45,5%. There was no significant
correlation between TAMs and LVD in breast
carcinoma.(p=0,545),CI
95%
(0,439 � 4,757).
Conclusions : In this study TAMs have not play a
significant role in lymphovascular density in breast
carcinoma. |
| first_indexed | 2024-03-13T23:18:29Z |
| format | Thesis |
| id | oai:generic.eprints.org:127810 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:18:29Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1278102016-03-04T07:56:10Z https://repository.ugm.ac.id/127810/ HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR PADA KARSINOMA PAYUDARA , FERDINANDUS BAYU SATRIA , dr. Irianiwati,Sp.PA(K), ETD Background : Lymphovascular Density (LVD) is a significant indicator of lymphangiogenesis process and it has important role in cancer metastatic. TAMs are activated macrophages which induce angiogenesis,tumor invasion and migration. In breast carcinoma, the protumoral characters of TAMs is more dominant than the antitumoral ones. The correlation between the number of TAMs and LVD in breast carcinoma is still unclear. Aim: To know the correlation between the number of TAMs with LVD in breast carcinoma. Methods : 44 samples of invasive ductal carcinoma of the breast from Sardjito Hospital 2009 were observed in this study. These samples were stained immunohistochemically by anti CD-68 and anti D2-40 monoclonal antibody. Number of TAMs were determined by counting the number of macrophages which expressed CD68 within 5 hot spot areas. Number of LVD was determined by counting the number of lymphatic vessel which it�s endothelial cells expressed D2-40 within 5 hot spot areas. TAMs and LVD were grouped into high and low based on median value as cut-off. Correlation between the number of TAMs and LVD will be analyzed using Pearson Chi-Square Test correlation. Results: cut-off point of TAMs was 49. Frequency of high TAMs: 50%, low: 50%. Frequency of samples with high LVD: 54,5%, low: 45,5%. There was no significant correlation between TAMs and LVD in breast carcinoma.(p=0,545),CI 95% (0,439 � 4,757). Conclusions : In this study TAMs have not play a significant role in lymphovascular density in breast carcinoma. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , FERDINANDUS BAYU SATRIA and , dr. Irianiwati,Sp.PA(K), (2014) HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR PADA KARSINOMA PAYUDARA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68100 |
| spellingShingle | ETD , FERDINANDUS BAYU SATRIA , dr. Irianiwati,Sp.PA(K), HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR PADA KARSINOMA PAYUDARA |
| title | HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR
PADA KARSINOMA PAYUDARA |
| title_full | HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR
PADA KARSINOMA PAYUDARA |
| title_fullStr | HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR
PADA KARSINOMA PAYUDARA |
| title_full_unstemmed | HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR
PADA KARSINOMA PAYUDARA |
| title_short | HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES ( TAMs ) DENGAN KEPADATAN LIMFOVASKULAR
PADA KARSINOMA PAYUDARA |
| title_sort | hubungan antara tumor associated macrophages tams dengan kepadatan limfovaskular pada karsinoma payudara |
| topic | ETD |
| work_keys_str_mv | AT ferdinandusbayusatria hubunganantaratumorassociatedmacrophagestamsdengankepadatanlimfovaskularpadakarsinomapayudara AT dririaniwatisppak hubunganantaratumorassociatedmacrophagestamsdengankepadatanlimfovaskularpadakarsinomapayudara |