UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION
Background : pathogenic fungi infection is still an issue in medical discourse nowadays. In the last two decades, Candida sp. has been reported to change from being the opportunist fungus that rarely caused nosocomial infection to be the opportunist fungus that most often cause nosocomial infection....
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826047901824974848 |
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| author | , ANDRIANI ADILLA K.W , dr. Titik Nuryastuti, M.Si, Ph.D |
| author_facet | , ANDRIANI ADILLA K.W , dr. Titik Nuryastuti, M.Si, Ph.D |
| author_sort | , ANDRIANI ADILLA K.W |
| collection | UGM |
| description | Background : pathogenic fungi infection is still an
issue in medical discourse nowadays. In the last two
decades, Candida sp. has been reported to change from
being the opportunist fungus that rarely caused
nosocomial infection to be the opportunist fungus that
most often cause nosocomial infection. Candidiasis
treatment that is effective and efficient is needed,
but to this day there are many antifungal treatments
that is improper and irrational in dosage, thus
resulting in resistance. One of the fungi that is
resistant to conventional antifungal treatment is
Candida sp resistant Itrakonazol and Ketokonazol. The
effort in finding new antifungal can be done through
pharmacomodulation of compounds which activity has been
known. Mustofa et al (2002) have succeeded in
developing derivative compound 1,10-Fenantrolin, that
is in the form of Fenatrolin 2 compound in the way of
modifying the structure of the compound.
Objective : to find out the antifungal potential, which
is the Minimum Inhibitory Concentration (MIC) of the
Fenantrolin 2 compound against strain of Candida sp
resistant Itrakonazol and Ketokonazol.
Methods : this research was conducted with experimental
descriptive design and antifungal potential through
microboth dilution method.
Results : the result obtained is based on the test
showing that a strain of Candida sp resistant
Itrakonazol and Ketokonazol growth can be restricted by
Fenantrolin 2 compound in 3,175 µg/ml concentrations.
Conclusion : Fenantrolin 2 has the antifungal potential
towards Candida sp resistant Itrakonazol and
Ketokonazol which action mechanism is not fully
understood. |
| first_indexed | 2024-03-13T23:18:29Z |
| format | Thesis |
| id | oai:generic.eprints.org:127813 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:18:29Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1278132016-03-04T07:52:11Z https://repository.ugm.ac.id/127813/ UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION , ANDRIANI ADILLA K.W , dr. Titik Nuryastuti, M.Si, Ph.D ETD Background : pathogenic fungi infection is still an issue in medical discourse nowadays. In the last two decades, Candida sp. has been reported to change from being the opportunist fungus that rarely caused nosocomial infection to be the opportunist fungus that most often cause nosocomial infection. Candidiasis treatment that is effective and efficient is needed, but to this day there are many antifungal treatments that is improper and irrational in dosage, thus resulting in resistance. One of the fungi that is resistant to conventional antifungal treatment is Candida sp resistant Itrakonazol and Ketokonazol. The effort in finding new antifungal can be done through pharmacomodulation of compounds which activity has been known. Mustofa et al (2002) have succeeded in developing derivative compound 1,10-Fenantrolin, that is in the form of Fenatrolin 2 compound in the way of modifying the structure of the compound. Objective : to find out the antifungal potential, which is the Minimum Inhibitory Concentration (MIC) of the Fenantrolin 2 compound against strain of Candida sp resistant Itrakonazol and Ketokonazol. Methods : this research was conducted with experimental descriptive design and antifungal potential through microboth dilution method. Results : the result obtained is based on the test showing that a strain of Candida sp resistant Itrakonazol and Ketokonazol growth can be restricted by Fenantrolin 2 compound in 3,175 µg/ml concentrations. Conclusion : Fenantrolin 2 has the antifungal potential towards Candida sp resistant Itrakonazol and Ketokonazol which action mechanism is not fully understood. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , ANDRIANI ADILLA K.W and , dr. Titik Nuryastuti, M.Si, Ph.D (2014) UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68106 |
| spellingShingle | ETD , ANDRIANI ADILLA K.W , dr. Titik Nuryastuti, M.Si, Ph.D UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title | UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title_full | UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title_fullStr | UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title_full_unstemmed | UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title_short | UJI POTENSI ANTIJAMUR SENYAWA FENANTROLIN 2 TERHADAP STRAIN Candida sp Resisten Itrakonazol dan Ketokonazol DENGAN METODE MICROBROTH DILUTION |
| title_sort | uji potensi antijamur senyawa fenantrolin 2 terhadap strain candida sp resisten itrakonazol dan ketokonazol dengan metode microbroth dilution |
| topic | ETD |
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