Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2008
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| Online Access: | http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf |
| _version_ | 1796876003830661120 |
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| author | Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari |
| author_facet | Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari |
| author_sort | Jaafar, Khairul Azhar |
| collection | IIUM |
| description | Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment.
Methods: We retrospectively looked into CHC patients selected for treatment from 2005 - 2007,Kuantan Hospital, Malaysia. Fifteen patients were identified between the ages of 19 - 58 years. Blood results for HCV RNA viral load, genotyping, lipid profile, liver biopsy (Ishak et al score) and body mass index (BMI) were documented pretreatment.
Results: Seven patients were genotype 1, 6 patients were genotype 3 and 1 patient each for genotype 2 and 6 respectively. Majority of patients had mild hepatic steatosis, 60% (n=9/15) pretreatment and highest were among genotype 1, 33.3% (n=5/15), followed by genotype 3, 20% (n=3/15) and genotype 2, 6% (n=1/15). Among them, 8 out of 15 (53.3%) patients had normal trigliseride (TG) level, 5 out of 15 (33.3%) patients had BMI <25 and 6 out of 15
(40%) patients had high viral load (HVL, >400,000 iu/ml).
Conclusions: We observed that the majority of patients with CHC had mild hepatic steatosis, 60% (n=9/15) with normal TG, 53.3% (n=8/15) and amongst genotype 1, 33.3% (n=5/15). Higher viral load might have an influence in the development and progression of steatosis in CHC. |
| first_indexed | 2024-03-05T22:46:20Z |
| format | Article |
| id | oai:generic.eprints.org:12784 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:46:20Z |
| publishDate | 2008 |
| publisher | Springer |
| record_format | dspace |
| spelling | oai:generic.eprints.org:127842012-01-05T04:12:37Z http://irep.iium.edu.my/12784/ Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari R Medicine (General) Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment from 2005 - 2007,Kuantan Hospital, Malaysia. Fifteen patients were identified between the ages of 19 - 58 years. Blood results for HCV RNA viral load, genotyping, lipid profile, liver biopsy (Ishak et al score) and body mass index (BMI) were documented pretreatment. Results: Seven patients were genotype 1, 6 patients were genotype 3 and 1 patient each for genotype 2 and 6 respectively. Majority of patients had mild hepatic steatosis, 60% (n=9/15) pretreatment and highest were among genotype 1, 33.3% (n=5/15), followed by genotype 3, 20% (n=3/15) and genotype 2, 6% (n=1/15). Among them, 8 out of 15 (53.3%) patients had normal trigliseride (TG) level, 5 out of 15 (33.3%) patients had BMI <25 and 6 out of 15 (40%) patients had high viral load (HVL, >400,000 iu/ml). Conclusions: We observed that the majority of patients with CHC had mild hepatic steatosis, 60% (n=9/15) with normal TG, 53.3% (n=8/15) and amongst genotype 1, 33.3% (n=5/15). Higher viral load might have an influence in the development and progression of steatosis in CHC. Springer 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf Jaafar, Khairul Azhar and Hasmoni, Mohamed Hadzri and Abdul Rashid, Mohd Amran and Md Ralib @ Md Raghib, Ahmad Razali and H, Nora and Satwi, Sapari (2008) Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis. Hepatology International, 2 (Supp). S513-S514. ISSN 1936-0533 http://www.springerlink.com/content/633706w4251m092w/fulltext.pdf |
| spellingShingle | R Medicine (General) Jaafar, Khairul Azhar Hasmoni, Mohamed Hadzri Abdul Rashid, Mohd Amran Md Ralib @ Md Raghib, Ahmad Razali H, Nora Satwi, Sapari Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis |
| title | Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
|
| title_full | Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
|
| title_fullStr | Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
|
| title_full_unstemmed | Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
|
| title_short | Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis
|
| title_sort | hepatic steatosis among chronic hepatitis c infected patients selected for treatment a retrospective analysis |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/12784/1/hepatic_steatosis_among_chronic_hepatitis.pdf |
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