ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA
Background: Hepatitis B Virus (HBV) infection is a major public health problem. Approximately, more than 2 billion people are infected with HBV and there are 350 million chronic carriers around the world. Every year, more than half a million people are dead due to acute or chronic infection of HBV....
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826047928615043072 |
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| author | , SAGITA ADVENTIA , dr. Didik Setyo Heriyanto, Ph.D, Sp.PA |
| author_facet | , SAGITA ADVENTIA , dr. Didik Setyo Heriyanto, Ph.D, Sp.PA |
| author_sort | , SAGITA ADVENTIA |
| collection | UGM |
| description | Background: Hepatitis B Virus (HBV) infection is a major
public health problem. Approximately, more than 2 billion
people are infected with HBV and there are 350 million
chronic carriers around the world. Every year, more than
half a million people are dead due to acute or chronic
infection of HBV. Indonesia is categorized into a country
with medium until high endemicity of HBV with carrier
rate around 5�20% among population. Studies about viral
factors, especially HBV mutation which contributed into
the development of advanced liver diseases have been
conducted. However, the results remain inconclusive.
Thus, this research is focused on the identification of
specific mutation in X gene of HBV which could be used as
a predictive marker for advanced liver diseases.
Objective: To know prevalence of X gene mutation T1631C
and C1638 in patients with chronic HBV infection and
advanced liver diseases in RSUP Dr. Sardjito Yogyakarta.
Methods: Cross-sectional study involved 80 patients with
positive HBsAg status in RSUP Dr. Sardjito Yogyakarta.
Patients are divided into two groups, 40 patients with
chronic HBV infection and 40 patients with advanced liver
diseases. X gene mutation is analysed by nested PCR and
direct sequencing.
Results: X gene mutation in C1638T and T1631C were found
in 19 (47,5%) and 18 (45%) of 40 advanced liver diseases
patients, respectively. In the group of patients with
chronic HBV infection, mutation in C1638T and T1631C were
only found in 2 (5%) and 2 (5%) of 40 patients,
recpectively. This difference is statistically
significant.
Conclusion: X gene mutation in C1638T and T1631C are more
prevalent in group of patients with advanced liver
diseases compared with group of patients with chronic HBV
infection. Therefore, X gene mutation could be used as
predictive marker for advanced liver diseases development
process. |
| first_indexed | 2024-03-13T23:18:54Z |
| format | Thesis |
| id | oai:generic.eprints.org:127947 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:18:54Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1279472016-03-04T08:11:40Z https://repository.ugm.ac.id/127947/ ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA , SAGITA ADVENTIA , dr. Didik Setyo Heriyanto, Ph.D, Sp.PA ETD Background: Hepatitis B Virus (HBV) infection is a major public health problem. Approximately, more than 2 billion people are infected with HBV and there are 350 million chronic carriers around the world. Every year, more than half a million people are dead due to acute or chronic infection of HBV. Indonesia is categorized into a country with medium until high endemicity of HBV with carrier rate around 5�20% among population. Studies about viral factors, especially HBV mutation which contributed into the development of advanced liver diseases have been conducted. However, the results remain inconclusive. Thus, this research is focused on the identification of specific mutation in X gene of HBV which could be used as a predictive marker for advanced liver diseases. Objective: To know prevalence of X gene mutation T1631C and C1638 in patients with chronic HBV infection and advanced liver diseases in RSUP Dr. Sardjito Yogyakarta. Methods: Cross-sectional study involved 80 patients with positive HBsAg status in RSUP Dr. Sardjito Yogyakarta. Patients are divided into two groups, 40 patients with chronic HBV infection and 40 patients with advanced liver diseases. X gene mutation is analysed by nested PCR and direct sequencing. Results: X gene mutation in C1638T and T1631C were found in 19 (47,5%) and 18 (45%) of 40 advanced liver diseases patients, respectively. In the group of patients with chronic HBV infection, mutation in C1638T and T1631C were only found in 2 (5%) and 2 (5%) of 40 patients, recpectively. This difference is statistically significant. Conclusion: X gene mutation in C1638T and T1631C are more prevalent in group of patients with advanced liver diseases compared with group of patients with chronic HBV infection. Therefore, X gene mutation could be used as predictive marker for advanced liver diseases development process. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , SAGITA ADVENTIA and , dr. Didik Setyo Heriyanto, Ph.D, Sp.PA (2014) ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68267 |
| spellingShingle | ETD , SAGITA ADVENTIA , dr. Didik Setyo Heriyanto, Ph.D, Sp.PA ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title | ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title_full | ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title_fullStr | ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title_full_unstemmed | ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title_short | ANALISIS MUTASI T1631C DAN C1638T DI GENA X PADA PASIEN DENGAN HEPATITIS B KRONIS DAN PENYAKIT HATI TAHAP LANJUT DI RSUP DR. SARDJITO YOGYAKARTA |
| title_sort | analisis mutasi t1631c dan c1638t di gena x pada pasien dengan hepatitis b kronis dan penyakit hati tahap lanjut di rsup dr sardjito yogyakarta |
| topic | ETD |
| work_keys_str_mv | AT sagitaadventia analisismutasit1631cdanc1638tdigenaxpadapasiendenganhepatitisbkronisdanpenyakithatitahaplanjutdirsupdrsardjitoyogyakarta AT drdidiksetyoheriyantophdsppa analisismutasit1631cdanc1638tdigenaxpadapasiendenganhepatitisbkronisdanpenyakithatitahaplanjutdirsupdrsardjitoyogyakarta |