| Summary: | Background: Centella asiatica sp. (pegagan) has neurotropic
and neuroprotective properties which inhibit deterioration of
memory because of chronic electrical stress. Studies about
effective dose of Centtela asiatica still continued.
Objective: To discover the influence of pegagan extract�s dose
variation intake towards memory after chronic stress.
Method: This study uses that true experimental design with
pretest-posttest control design. Subjects are 15 male Sprague
Dawley rats. The rats were divided into three groups. Every
groups are treated with chronic electrical stress for 4 weeks
and aquades (KN), 300mg/kgBW/day of Centella asiatica (KN1) or
600 mg/kgBW/day of Centella asiatica (KP2). The latency
distance measure from Morris water maze was used to measure
rats� memory. Kolmogorov-Smirnov is used to observe the
normality of distribution, ANOVA test to compare the measure
between different groups and paired t-test to compare pretest
and posttest effects.
Result: The average of latency distance before chronic
electrical stress are 5,71±0,77m (KN)
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