THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME
Background: Metabolic syndrome is often associated as a major risk factor for cardiovascular disease and increases risk for type 2 diabetes mellitus. The pathogenesis of the metabolic syndrome and each of its components is complex and not well understood. However, central obesity and insulin resista...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797034891348541440 |
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| author | , LEE JAY MIE , Dr. Cornelia Wahyu Danawati, Ph.D. Sp.PD |
| author_facet | , LEE JAY MIE , Dr. Cornelia Wahyu Danawati, Ph.D. Sp.PD |
| author_sort | , LEE JAY MIE |
| collection | UGM |
| description | Background: Metabolic syndrome is often associated as a major risk factor for cardiovascular disease and increases risk for type 2 diabetes mellitus. The pathogenesis of the metabolic syndrome and each of its components is complex and not well understood. However, central obesity and insulin resistance are widely accepted and acknowledged by many studies as important causative factors.
Aim: The study was aimed at exploring whether metformin and valsartan in combination can help improve central obesity, thus reducing the waist circumference of the patient.
Method: The research design was one group pre test- post test design of a quasi experiment. 22 patients who were under treatment at the internal medicine endocrinology polyclinic of Dr. Sardjito Hospital, Yogyakarta were recruited as subjects. The change of waist circumference at the end of 12 weeks of drug intervention was evaluated using paired- sample T test.
Results: The result revealed that metformin and valsartan increased the waist circumference by 0,750± 3,497, as opposed to the hypothesis (P= 0,326).
Conclusion: Metformin and valsartan therapy increase the waist circumference of patient with metabolic syndrome. However, the result is insignificant. |
| first_indexed | 2024-03-13T23:19:16Z |
| format | Thesis |
| id | oai:generic.eprints.org:128001 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:19:16Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1280012016-03-04T07:58:14Z https://repository.ugm.ac.id/128001/ THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME , LEE JAY MIE , Dr. Cornelia Wahyu Danawati, Ph.D. Sp.PD ETD Background: Metabolic syndrome is often associated as a major risk factor for cardiovascular disease and increases risk for type 2 diabetes mellitus. The pathogenesis of the metabolic syndrome and each of its components is complex and not well understood. However, central obesity and insulin resistance are widely accepted and acknowledged by many studies as important causative factors. Aim: The study was aimed at exploring whether metformin and valsartan in combination can help improve central obesity, thus reducing the waist circumference of the patient. Method: The research design was one group pre test- post test design of a quasi experiment. 22 patients who were under treatment at the internal medicine endocrinology polyclinic of Dr. Sardjito Hospital, Yogyakarta were recruited as subjects. The change of waist circumference at the end of 12 weeks of drug intervention was evaluated using paired- sample T test. Results: The result revealed that metformin and valsartan increased the waist circumference by 0,750± 3,497, as opposed to the hypothesis (P= 0,326). Conclusion: Metformin and valsartan therapy increase the waist circumference of patient with metabolic syndrome. However, the result is insignificant. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , LEE JAY MIE and , Dr. Cornelia Wahyu Danawati, Ph.D. Sp.PD (2014) THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68324 |
| spellingShingle | ETD , LEE JAY MIE , Dr. Cornelia Wahyu Danawati, Ph.D. Sp.PD THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title | THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title_full | THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title_fullStr | THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title_full_unstemmed | THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title_short | THE EFFECT OF COMBINATION USE OF METFORMIN AND VALSARTAN ON THE WAIST CIRCUMFERENCE OF PATIENT WITH METABOLIC SYNDROME |
| title_sort | effect of combination use of metformin and valsartan on the waist circumference of patient with metabolic syndrome |
| topic | ETD |
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