UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D
Background: Cancer is one of the main causes of death in 2008, and breast cancer is the most common cancer in females worldwide. Non-operative therapy modalities of breast cancer give great benefits, although they have many side effects and even resistency. Isoflavone, a kind of phytoestrogen, is th...
| Main Authors: | , |
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797034911346982912 |
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| author | , GARNISA ARSYI AOTEAROA , Dra. Sri Herwiyanti, M.S. |
| author_facet | , GARNISA ARSYI AOTEAROA , Dra. Sri Herwiyanti, M.S. |
| author_sort | , GARNISA ARSYI AOTEAROA |
| collection | UGM |
| description | Background: Cancer is one of the main causes of death
in 2008, and breast cancer is the most common cancer in
females worldwide. Non-operative therapy modalities of
breast cancer give great benefits, although they have
many side effects and even resistency. Isoflavone, a
kind of phytoestrogen, is thought to play a beneficial
role in preventing breast cancer and may functions as
antiestrogens/weak estrogen. Isoflavone derivates are
expected to have cytotoxic activity on breast cancer
cell line culture MCF-7 and T47D.
Objectives: This study was intended to know the
cytotoxic activity of novel substance 7-O�benzoyl�3,4-
dimetoxyisoflavone on breast cancer cell line culture
MCF-7 and T47D.
Method: The cytotoxicity of the substance was tested
against breast cancer cell line MCF-7 and T47D using
MTT assay with serial concentration. The IC50 value was
obtained using probit regression analysis.
Result: The IC50 value of 7-O�benzoyl�3,4-
dimetoxyisoflavone in cell lines MCF-7 was 150,320
±105,75 µg/mL whereas in cell lines T47D was 105,888
µg/ml ±90,74. The IC50 value of doxorubicin in cell
lines MCF-7 was 5,735 ±4,79 µg/mL whereas in cell lines
T47D was 36,763 µg/ml.
Conclusion: Novel substance 7-O-benzoil-3,4-
dimetoksiisoflavon does not have cytotoxic activity
against breast cancer cell line MCF-7 and T47D. |
| first_indexed | 2024-03-13T23:19:38Z |
| format | Thesis |
| id | oai:generic.eprints.org:128102 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:19:38Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1281022016-03-04T07:56:31Z https://repository.ugm.ac.id/128102/ UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D , GARNISA ARSYI AOTEAROA , Dra. Sri Herwiyanti, M.S. ETD Background: Cancer is one of the main causes of death in 2008, and breast cancer is the most common cancer in females worldwide. Non-operative therapy modalities of breast cancer give great benefits, although they have many side effects and even resistency. Isoflavone, a kind of phytoestrogen, is thought to play a beneficial role in preventing breast cancer and may functions as antiestrogens/weak estrogen. Isoflavone derivates are expected to have cytotoxic activity on breast cancer cell line culture MCF-7 and T47D. Objectives: This study was intended to know the cytotoxic activity of novel substance 7-O�benzoyl�3,4- dimetoxyisoflavone on breast cancer cell line culture MCF-7 and T47D. Method: The cytotoxicity of the substance was tested against breast cancer cell line MCF-7 and T47D using MTT assay with serial concentration. The IC50 value was obtained using probit regression analysis. Result: The IC50 value of 7-O�benzoyl�3,4- dimetoxyisoflavone in cell lines MCF-7 was 150,320 ±105,75 µg/mL whereas in cell lines T47D was 105,888 µg/ml ±90,74. The IC50 value of doxorubicin in cell lines MCF-7 was 5,735 ±4,79 µg/mL whereas in cell lines T47D was 36,763 µg/ml. Conclusion: Novel substance 7-O-benzoil-3,4- dimetoksiisoflavon does not have cytotoxic activity against breast cancer cell line MCF-7 and T47D. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , GARNISA ARSYI AOTEAROA and , Dra. Sri Herwiyanti, M.S. (2014) UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68432 |
| spellingShingle | ETD , GARNISA ARSYI AOTEAROA , Dra. Sri Herwiyanti, M.S. UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title | UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title_full | UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title_fullStr | UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title_full_unstemmed | UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title_short | UJI SITOTOKSISITAS SENYAWA 7-O-BENZOIL-3,4- DIMETOKSIISOFLAVON HASIL SINTESIS PADA KULTUR CELL LINE KANKER PAYUDARA MCF-7 DAN T47D |
| title_sort | uji sitotoksisitas senyawa 7 o benzoil 3 4 dimetoksiisoflavon hasil sintesis pada kultur cell line kanker payudara mcf 7 dan t47d |
| topic | ETD |
| work_keys_str_mv | AT garnisaarsyiaotearoa ujisitotoksisitassenyawa7obenzoil34dimetoksiisoflavonhasilsintesispadakulturcelllinekankerpayudaramcf7dant47d AT drasriherwiyantims ujisitotoksisitassenyawa7obenzoil34dimetoksiisoflavonhasilsintesispadakulturcelllinekankerpayudaramcf7dant47d |