PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA
Backgrounds: Cancers the leading causes of death worldwide. Lung cancer ranks first contributor to cancer deaths. In cancer occurs increase of cell proliferation. Isoflavone is compounds that have potential as anticancer by inhibiting cell proliferation. In this research, isoflavone derivative compo...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826047971390652416 |
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| author | , EIDA AGISA DEWI , Dra. Sri Herwiyanti, M.S |
| author_facet | , EIDA AGISA DEWI , Dra. Sri Herwiyanti, M.S |
| author_sort | , EIDA AGISA DEWI |
| collection | UGM |
| description | Backgrounds: Cancers the leading causes of death
worldwide. Lung cancer ranks first contributor to cancer
deaths. In cancer occurs increase of cell proliferation.
Isoflavone is compounds that have potential as anticancer
by inhibiting cell proliferation. In this research,
isoflavone derivative compounds of clove oil (eugenol),
1,2-Epoksi-3[3-(3�4�-dimetoksifenil)-4H-1-benzopiran-4-
on] propane (EPI) expected to decrease the proliferation
of alveolar cells.
Objectives: To know the effect of EPI compounds on
alveolar cell proliferation of white rat (Sprague Dawley)
cancer model which induced by DMBA with parameter IHC
anti-PCNA.
Methods: The subject used is 36 white rats (Sprague
Dawley) female, 2 weeks old, and ± 40 gram in weight.
Subject was divided into 6 groups randomly. Control
group, fed only. Oil group, were given corn oil (solvent
DMBA). DMBA group, were given DMBA 2x20mg/kgBB for 5
weeks, a rat model cancer. EPI 1 mg group, rat model
cancers were given isoflavone compounds 1mg/kgBB for 15
weeks. EPI 2 mg group, rat model cancers were given
isoflavone compounds 2mg/kgBB for 15 weeks. EPI 4 mg
group, rat model cancers were given isoflavone compounds
4mg/kgBB for 15 weeks. After completion, the sample of
lung was staining with IHC anti-PCNA.
Results: DMBA increase the number of alveolar cells that
express PCNA (p<0,05). Isoflavone 1 mg and isoflavone 2
mg does not decrease the number of alveolar cells that
express PCNA (p<0,05). Isoflavone 4 mg decrease the
number of alveolar cells that express PCNA (p>0,05).
Conclusion: Isoflavone 4 mg able to decrease the
proliferation of alveolar cells in the white rat (Sprague
Dawley) cancer model which induced by DMBA. |
| first_indexed | 2024-03-13T23:20:03Z |
| format | Thesis |
| id | oai:generic.eprints.org:128160 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:20:03Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1281602016-03-04T07:55:24Z https://repository.ugm.ac.id/128160/ PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA , EIDA AGISA DEWI , Dra. Sri Herwiyanti, M.S ETD Backgrounds: Cancers the leading causes of death worldwide. Lung cancer ranks first contributor to cancer deaths. In cancer occurs increase of cell proliferation. Isoflavone is compounds that have potential as anticancer by inhibiting cell proliferation. In this research, isoflavone derivative compounds of clove oil (eugenol), 1,2-Epoksi-3[3-(3�4�-dimetoksifenil)-4H-1-benzopiran-4- on] propane (EPI) expected to decrease the proliferation of alveolar cells. Objectives: To know the effect of EPI compounds on alveolar cell proliferation of white rat (Sprague Dawley) cancer model which induced by DMBA with parameter IHC anti-PCNA. Methods: The subject used is 36 white rats (Sprague Dawley) female, 2 weeks old, and ± 40 gram in weight. Subject was divided into 6 groups randomly. Control group, fed only. Oil group, were given corn oil (solvent DMBA). DMBA group, were given DMBA 2x20mg/kgBB for 5 weeks, a rat model cancer. EPI 1 mg group, rat model cancers were given isoflavone compounds 1mg/kgBB for 15 weeks. EPI 2 mg group, rat model cancers were given isoflavone compounds 2mg/kgBB for 15 weeks. EPI 4 mg group, rat model cancers were given isoflavone compounds 4mg/kgBB for 15 weeks. After completion, the sample of lung was staining with IHC anti-PCNA. Results: DMBA increase the number of alveolar cells that express PCNA (p<0,05). Isoflavone 1 mg and isoflavone 2 mg does not decrease the number of alveolar cells that express PCNA (p<0,05). Isoflavone 4 mg decrease the number of alveolar cells that express PCNA (p>0,05). Conclusion: Isoflavone 4 mg able to decrease the proliferation of alveolar cells in the white rat (Sprague Dawley) cancer model which induced by DMBA. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , EIDA AGISA DEWI and , Dra. Sri Herwiyanti, M.S (2014) PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68495 |
| spellingShingle | ETD , EIDA AGISA DEWI , Dra. Sri Herwiyanti, M.S PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title_full | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title_fullStr | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title_full_unstemmed | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title_short | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI- 3[3-[3,4-DIMETOKSIFENIL]-4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP PROLIFERASI SEL ALVEOLUS PARU PADA TIKUS PUTIH (SPRAGUE DAWLEY) MODEL KANKER YANG DIINDUKSI DMBA |
| title_sort | pengaruh pemberian senyawa turunan isoflavon 1 2 epoksi 3 3 3 4 dimetoksifenil 4h 1 benzopiran 4 on propana terhadap proliferasi sel alveolus paru pada tikus putih sprague dawley model kanker yang diinduksi dmba |
| topic | ETD |
| work_keys_str_mv | AT eidaagisadewi pengaruhpemberiansenyawaturunanisoflavon12epoksi3334dimetoksifenil4h1benzopiran4onpropanaterhadapproliferasiselalveolusparupadatikusputihspraguedawleymodelkankeryangdiinduksidmba AT drasriherwiyantims pengaruhpemberiansenyawaturunanisoflavon12epoksi3334dimetoksifenil4h1benzopiran4onpropanaterhadapproliferasiselalveolusparupadatikusputihspraguedawleymodelkankeryangdiinduksidmba |