| Summary: | Background: Hepatitis B infection is one of the most
common infection in the world which has a very high
morbidity and mortality. Indonesia is among the countries
in the world where the amount of people with hepatitis B
infection is very high. Chronic hepatitis B infection may
progress into advanced liver disease, and one of the
factor that may trigger the infection progressing into
advanced liver disease is the virus mutation. There are a
lot of mutation in hepatitis B virus, and one of them is
the G1896A mutation in precore region. Several studies
that has been conducted in other countries suggest this
mutation is one of the factor that will increase the risk
of hepatitis B chronic infection in becoming advanced
liver disease. However, the study on G1896A mutation in
RSUP Dr. Sardjito Yogyakarta has not been conducted.
Objective: To investigate the difference of prevalence of
G1896A mutation between patient with chronic hepatitis B
infection and advanced liver disease.
Methods: Observational cross-sectional study, involving
80 patients that were divided into 2 groups. The first
group consist of patients with either liver cirrhosis or
hepatocellular carcinoma which were grouped as advanced
liver disease (n=40, 31 male and 9 female, mean age
54.38±11.58 years old), and the second group consist of
patients with chronic hepatitis B infection (n=40, 27
male and 13 female, mean age 36.63±12,76 years old). The
analysis was being done during period of September
through December 2013. The chronic hepatitis B infection
is patient who have the positive in HBsAg test, but did
not fulfill any diagnosis criteria of either liver
cirrhosis or hepatocellular carcinoma. The mutation then
analyzed with direct sequencing method.
Results: The presence of G1896A mutation were observed in
16(40%) patients with advanced liver disease and
11(27.5%) patients with chronic hepatitis B infection.
The difference of G1896A mutation prevalence between the
two groups is not statistically significant.
Conclusion: There is no significant difference in the
presence of G1896A mutation between patient with advanced
liver disease and patient with chronic hepatitis B
infection. However, there is a trend that the prevalence
of G1896A mutation among the patient with advanced liver
disease is a little bit higher, which may suggest that
G1896A mutation may have a role in triggering the change
of course from chronic hepatitis B infection into
advanced liver disease.
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