PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA
Isofalvone is a compound whinch can be found abundantly in soy. Isoflavone has a protective effect on liver againts peroxidative damage by enhanching antioxidant activity. The aim of this research is to study the influence of isoflavone compound, 1,2-epoksi-3-[3- (3�,4�-dimetoksifenil)4H-1-benzo...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: |
| _version_ | 1797034940552970240 |
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| author | , SEPTERINA PURWASETYA , Dra. Sri Herwiyanti, MS |
| author_facet | , SEPTERINA PURWASETYA , Dra. Sri Herwiyanti, MS |
| author_sort | , SEPTERINA PURWASETYA |
| collection | UGM |
| description | Isofalvone is a compound whinch can be found
abundantly in soy. Isoflavone has a protective effect
on liver againts peroxidative damage by enhanching
antioxidant activity.
The aim of this research is to study the
influence of isoflavone compound, 1,2-epoksi-3-[3-
(3�,4�-dimetoksifenil)4H-1-benzopiran-4on]propana
(EPI), sintesized from clove leaves oil (eugenol), to
histological feature of liver especially liver
degeneration on Sprague Dawley strain rats (Rattus
norvegicus) whinch induced by DMBA.
Thirty-six female rats were randomly divided
into 6 groups of 6 rats. Normal control group was
treated with standar diet only. DMBA group was
treated with standard diet and 20mg/kgBW DMBA. The
DMBA used in this study was diluted in corn oil. The
corn oil group was treated with standard diet and
corn oil. Three treatment groups were treated with
standard diet, DMBA and EPI with 1mg/kgBW, 2mg/kgBW
and 4mg/kgBW dose respectively. DMBA induction were
done twice a week for 5 weeks. Standard diet and EPI
were given once a day for 15 weeks. On weeks 16th,
all groups were terminated and the liver was taken.
Histological specimens of the liver were prepared and
stained with haematoxyline-eosin. Liver degeneration
level was examined under light microscope using 100x
and 400x magnification in 5 observation field.
The result showed that EPI 2mg and 4mg groups
has lower level of liver degeneration compared to
DMBA group (p<0,05). Therefore, it conclude that EPI
with 2mg/kgBW and 4mg/kgBW dose was able to reduce
liver degeneration of rats induced by DMBA. |
| first_indexed | 2024-03-13T23:20:19Z |
| format | Thesis |
| id | oai:generic.eprints.org:128248 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:20:19Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1282482016-03-04T08:12:14Z https://repository.ugm.ac.id/128248/ PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA , SEPTERINA PURWASETYA , Dra. Sri Herwiyanti, MS ETD Isofalvone is a compound whinch can be found abundantly in soy. Isoflavone has a protective effect on liver againts peroxidative damage by enhanching antioxidant activity. The aim of this research is to study the influence of isoflavone compound, 1,2-epoksi-3-[3- (3�,4�-dimetoksifenil)4H-1-benzopiran-4on]propana (EPI), sintesized from clove leaves oil (eugenol), to histological feature of liver especially liver degeneration on Sprague Dawley strain rats (Rattus norvegicus) whinch induced by DMBA. Thirty-six female rats were randomly divided into 6 groups of 6 rats. Normal control group was treated with standar diet only. DMBA group was treated with standard diet and 20mg/kgBW DMBA. The DMBA used in this study was diluted in corn oil. The corn oil group was treated with standard diet and corn oil. Three treatment groups were treated with standard diet, DMBA and EPI with 1mg/kgBW, 2mg/kgBW and 4mg/kgBW dose respectively. DMBA induction were done twice a week for 5 weeks. Standard diet and EPI were given once a day for 15 weeks. On weeks 16th, all groups were terminated and the liver was taken. Histological specimens of the liver were prepared and stained with haematoxyline-eosin. Liver degeneration level was examined under light microscope using 100x and 400x magnification in 5 observation field. The result showed that EPI 2mg and 4mg groups has lower level of liver degeneration compared to DMBA group (p<0,05). Therefore, it conclude that EPI with 2mg/kgBW and 4mg/kgBW dose was able to reduce liver degeneration of rats induced by DMBA. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , SEPTERINA PURWASETYA and , Dra. Sri Herwiyanti, MS (2014) PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68586 |
| spellingShingle | ETD , SEPTERINA PURWASETYA , Dra. Sri Herwiyanti, MS PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title_full | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title_fullStr | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title_full_unstemmed | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title_short | PENGARUH PEMBERIAN SENYAWA TURUNAN ISOFLAVON 1,2-EPOKSI-3-[3-(3�,4�-DIMETOKSIFENIL)4H-1-BENZOPIRAN-4-ON]PROPANA TERHADAP GAMBARAN HISTOLOGIS HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI DMBA |
| title_sort | pengaruh pemberian senyawa turunan isoflavon 1 2 epoksi 3 3 3a�� 4a�� dimetoksifenil 4h 1 benzopiran 4 on propana terhadap gambaran histologis hepar pada tikus putih rattus norvegicus galur sprague dawley yang diinduksi dmba |
| topic | ETD |
| work_keys_str_mv | AT septerinapurwasetya pengaruhpemberiansenyawaturunanisoflavon12epoksi333a4adimetoksifenil4h1benzopiran4onpropanaterhadapgambaranhistologisheparpadatikusputihrattusnorvegicusgalurspraguedawleyyangdiinduksidmba AT drasriherwiyantims pengaruhpemberiansenyawaturunanisoflavon12epoksi333a4adimetoksifenil4h1benzopiran4onpropanaterhadapgambaranhistologisheparpadatikusputihrattusnorvegicusgalurspraguedawleyyangdiinduksidmba |