PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS (Penelitian Imunohistokimiawi)
Chronic inflammation is immunity response due to persistence stimuli to the tissue.This may provoke prolonged on proliferation and metaplasia that may lead to malignancy. On the other hand this prolonged inflammation may have cytostatic effect which only found in benign lesion. Macrophage produces t...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| author | , Raden Rara Indradewi Sutikno , Drg. Bambang Dwirahardjo, SpBM |
| author_facet | , Raden Rara Indradewi Sutikno , Drg. Bambang Dwirahardjo, SpBM |
| author_sort | , Raden Rara Indradewi Sutikno |
| collection | UGM |
| description | Chronic inflammation is immunity response due to persistence stimuli to the
tissue.This may provoke prolonged on proliferation and metaplasia that may lead to
malignancy. On the other hand this prolonged inflammation may have cytostatic
effect which only found in benign lesion. Macrophage produces this cystostatic
effect through the induction of nitrit oxide and TNFα. Radicular cyst and dentigerous
cyst are benign lesions ,where inflammation is one thing in their common,but their
significant difference is found in their aggresivity.
This study was aimed to elaborate the influence of inflammatory response to the
epithelial proliferation in radicular cyst and dentigerous cyst in MMP 9
immunohistochemical staining.This was a retrospective analytic study using 10
dentigerous cyst samples and 9 radicular cyst sample, which all had
immunohistochemical staining using antigen of MMP 9. The macrophage and
epithelial surface were scored and having their correlation tested in Spearman Rank
test (α <0.025). There was a significant correlation among those variables both in
radicular cyst and (r=-0.667/p: 0.023) and dentigerous cyst (r=-0.495/p:0.14).
Inflammatory response had 44,48% capability to influence the epithel proliferation in
radicular cyst while only 24 % in dentigerous cyst.
Inflammatory response influenced the epithel proliferation in cyst. The higher
response achieved the lower proliferation rate is produced. In this study, the influence
of inflammatory response to the epithelial proliferation on dentigerous cyst is smaller
than the influence of inflammatory response to the epithelial proliferation on
radicular cyst. |
| first_indexed | 2024-03-13T23:20:24Z |
| format | Thesis |
| id | oai:generic.eprints.org:128276 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:20:24Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1282762016-03-04T08:11:01Z https://repository.ugm.ac.id/128276/ PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS (Penelitian Imunohistokimiawi) , Raden Rara Indradewi Sutikno , Drg. Bambang Dwirahardjo, SpBM ETD Chronic inflammation is immunity response due to persistence stimuli to the tissue.This may provoke prolonged on proliferation and metaplasia that may lead to malignancy. On the other hand this prolonged inflammation may have cytostatic effect which only found in benign lesion. Macrophage produces this cystostatic effect through the induction of nitrit oxide and TNFα. Radicular cyst and dentigerous cyst are benign lesions ,where inflammation is one thing in their common,but their significant difference is found in their aggresivity. This study was aimed to elaborate the influence of inflammatory response to the epithelial proliferation in radicular cyst and dentigerous cyst in MMP 9 immunohistochemical staining.This was a retrospective analytic study using 10 dentigerous cyst samples and 9 radicular cyst sample, which all had immunohistochemical staining using antigen of MMP 9. The macrophage and epithelial surface were scored and having their correlation tested in Spearman Rank test (α <0.025). There was a significant correlation among those variables both in radicular cyst and (r=-0.667/p: 0.023) and dentigerous cyst (r=-0.495/p:0.14). Inflammatory response had 44,48% capability to influence the epithel proliferation in radicular cyst while only 24 % in dentigerous cyst. Inflammatory response influenced the epithel proliferation in cyst. The higher response achieved the lower proliferation rate is produced. In this study, the influence of inflammatory response to the epithelial proliferation on dentigerous cyst is smaller than the influence of inflammatory response to the epithelial proliferation on radicular cyst. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Raden Rara Indradewi Sutikno and , Drg. Bambang Dwirahardjo, SpBM (2014) PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS (Penelitian Imunohistokimiawi). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68615 |
| spellingShingle | ETD , Raden Rara Indradewi Sutikno , Drg. Bambang Dwirahardjo, SpBM PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS (Penelitian Imunohistokimiawi) |
| title | PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS
(Penelitian Imunohistokimiawi) |
| title_full | PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS
(Penelitian Imunohistokimiawi) |
| title_fullStr | PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS
(Penelitian Imunohistokimiawi) |
| title_full_unstemmed | PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS
(Penelitian Imunohistokimiawi) |
| title_short | PENGARUH RESPON INFLAMASI TERHADAP PROLIFERASI SEL EPITEL DENGAN IMUNOEKSPRESI MATRIKS METALLOPROTEINASE 9 (MMP9) PADA KISTA RADIKULAR DAN KISTA DENTIGEROUS
(Penelitian Imunohistokimiawi) |
| title_sort | pengaruh respon inflamasi terhadap proliferasi sel epitel dengan imunoekspresi matriks metalloproteinase 9 mmp9 pada kista radikular dan kista dentigerous penelitian imunohistokimiawi |
| topic | ETD |
| work_keys_str_mv | AT radenraraindradewisutikno pengaruhresponinflamasiterhadapproliferasiselepiteldenganimunoekspresimatriksmetalloproteinase9mmp9padakistaradikulardankistadentigerouspenelitianimunohistokimiawi AT drgbambangdwirahardjospbm pengaruhresponinflamasiterhadapproliferasiselepiteldenganimunoekspresimatriksmetalloproteinase9mmp9padakistaradikulardankistadentigerouspenelitianimunohistokimiawi |