| Summary: | Introduction: Diabetes mellitus (DM) is one of the most prevalent non contagious diseases today and has attracted much attention. Diabetes mellitus can cause excessive glucose level in blood (Hyperglycemia). The increase in blood sugar can cause imbalance in lipid metabolism which causes changes in lipid profile in blood (Dyslipidemia). One of the most common changes found in DM patients is the excessive increase of triglyceride level in blood. Seed of mahogany, denominated in Latin by Swietenia macrophylla King, contains flavonoid, saponin, and alkaloid. Flavonoid compound in seeds of S. macrophylla King is identified as 7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-chroman-4-one. Results of previous researches has shown that extract of S. macrophylla King seed has both hypoglycemic and hypolipidemic effects. Therefore, further study of the effect of 7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-chroman-4-one towards blood glucose and triglyceride level of DM patient is necessary.
Objectives: The aim of this research is to investigate the effect of 7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-chroman-4-one in S. macrophylla King seed towards blood glucose and triglycerides levels in streptozotocin and nicotinamide induced Rattus norvegicus.
Methodology: This research is experimental with the utilization of pre-test and post-test control design by using 36 male laboratory mice (Rattus norvegicus) as subjects. The test subjects were divided into six groups
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