| Summary: | Background: Thrombocytopenia in sepsis may occur as a result of platelet activation,
either directly by endotoxin or proinflammatory cytokines. This situation is further resulted in
elevation of platelet consumption and coagulation proteins factor, and the widespread of
thrombosis and fibrin deposits in the microvascular. Microvascular thrombosis and subsequent
ischemic injury will contribute to the tissue injury and multiple organ dysfunction syndrome
(MODS). The severity of thrombocytopenia correlated with poor outcomes for septic
patients.The aim of research is to determine whether thrombocytopenia has predictive value for
septic patients mortality in the ICU of dr. Sardjito hospital.
Methods: Retrospective cohort study. Subjects: 92 septic patients who are hospitalized in
the ICU department of dr. Sardjito until October 2013. A total of 52 patients with
thrombocytopenia and 40 patients without thrombocytopenia. Platelets count, APACHE II score
and ICU outcomes were assessed.
Results : Outcomes died in group with thrombocytopenia are 46 patients (88.5 %) and
6 patients (11.5 %) survived, whereas patients died in the group without thrombocytopenia is as
many as 28 patients (70 %) and patients survived were 12 patients (30 %) . These results were
statistically significantly different (p < 0.05, p = 0.027) with the value of the RR (relative risk)
of 1.3 .There were significant differences between APACHE II score at admission ICU , 26.38
± 7.138 in group with thrombocytopenia and 22.02 ± 7.734 on group without trombositpenia
(p = 0.006) , as well as the APACHE II score in patients with thrombocytopenia who died
(27.28 ± 6.699) and survived (19.50 ± 7.176) (p = 0.011) . Mean platelet counts in patients with
thrombocytopenia who died are 66.02 ± 40.582 cells / mL while patients survived are 42.310 ±
90.17 cells / mL (p = 0.018) .
Conclusions : Thrombocytopenia is a predictor of mortality for septic patients in the ICU
Hospital Dr . Sardjito , where patients with thrombocytopenia had 1.3 times more likely to die
than patients without thrombocytopenia .
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