PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK
Background: Menignioma is a slow-growing benign brain tumors. The etiology of meningioma is still unknown, however gender-spesific hormones especially Progesterone Receptor (PR) is believed to have a role in the pathogenesis of this tumor. PR in meningioma influences tumor�s prediction and progres...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| Summary: | Background: Menignioma is a slow-growing benign brain
tumors. The etiology of meningioma is still unknown,
however gender-spesific hormones especially
Progesterone Receptor (PR) is believed to have a role
in the pathogenesis of this tumor. PR in meningioma
influences tumor�s prediction and progression. The role
of PR in benign meningioma based on age and gender is
still unclear.
Objective: This study aims to seek for differences
between PR�s expression in meningioma with variation of
age and gender.
Methods: This study was a descriptive comparative study
conducted retrospectively with the paraffin block of
all meningioma patients from year 2011-2012 that were
available at the Anatomical Pathology Laboratory Dr.
Sardjito�s hospital as subject. The samples were sliced
then examined by immunohistochemistry�s technic to
detect progesterone receptors expression. The average
age�s difference with PR expression in benign
meningioma was analyzed with Independent t test. The
different proportion of gender with PR�s expression was
analyzed with Fisher test.
Results: The study did not find any significant
difference of average age and PR�s expression, however
there were significant differences of gender proportion
with PR�s expression. The study shows that 50% of
meningiomas expressed progesterone reseptors with the
proportion of female patients (58,3%) higher than male
patients.
Conclusion: In this study, there was no significant
difference between PR�s expression and average ages but
there was significant difference with gender in beningn
orbitocranial meningiomas. |
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