PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK
Background: Menignioma is a slow-growing benign brain tumors. The etiology of meningioma is still unknown, however gender-spesific hormones especially Progesterone Receptor (PR) is believed to have a role in the pathogenesis of this tumor. PR in meningioma influences tumor�s prediction and progres...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| author | , BETHARI KUNTI ABIANTI , dr. Agus Supartoto, Sp.M(K). |
| author_facet | , BETHARI KUNTI ABIANTI , dr. Agus Supartoto, Sp.M(K). |
| author_sort | , BETHARI KUNTI ABIANTI |
| collection | UGM |
| description | Background: Menignioma is a slow-growing benign brain
tumors. The etiology of meningioma is still unknown,
however gender-spesific hormones especially
Progesterone Receptor (PR) is believed to have a role
in the pathogenesis of this tumor. PR in meningioma
influences tumor�s prediction and progression. The role
of PR in benign meningioma based on age and gender is
still unclear.
Objective: This study aims to seek for differences
between PR�s expression in meningioma with variation of
age and gender.
Methods: This study was a descriptive comparative study
conducted retrospectively with the paraffin block of
all meningioma patients from year 2011-2012 that were
available at the Anatomical Pathology Laboratory Dr.
Sardjito�s hospital as subject. The samples were sliced
then examined by immunohistochemistry�s technic to
detect progesterone receptors expression. The average
age�s difference with PR expression in benign
meningioma was analyzed with Independent t test. The
different proportion of gender with PR�s expression was
analyzed with Fisher test.
Results: The study did not find any significant
difference of average age and PR�s expression, however
there were significant differences of gender proportion
with PR�s expression. The study shows that 50% of
meningiomas expressed progesterone reseptors with the
proportion of female patients (58,3%) higher than male
patients.
Conclusion: In this study, there was no significant
difference between PR�s expression and average ages but
there was significant difference with gender in beningn
orbitocranial meningiomas. |
| first_indexed | 2024-03-13T23:22:24Z |
| format | Thesis |
| id | oai:generic.eprints.org:128727 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:22:24Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1287272016-03-04T07:53:19Z https://repository.ugm.ac.id/128727/ PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK , BETHARI KUNTI ABIANTI , dr. Agus Supartoto, Sp.M(K). ETD Background: Menignioma is a slow-growing benign brain tumors. The etiology of meningioma is still unknown, however gender-spesific hormones especially Progesterone Receptor (PR) is believed to have a role in the pathogenesis of this tumor. PR in meningioma influences tumor�s prediction and progression. The role of PR in benign meningioma based on age and gender is still unclear. Objective: This study aims to seek for differences between PR�s expression in meningioma with variation of age and gender. Methods: This study was a descriptive comparative study conducted retrospectively with the paraffin block of all meningioma patients from year 2011-2012 that were available at the Anatomical Pathology Laboratory Dr. Sardjito�s hospital as subject. The samples were sliced then examined by immunohistochemistry�s technic to detect progesterone receptors expression. The average age�s difference with PR expression in benign meningioma was analyzed with Independent t test. The different proportion of gender with PR�s expression was analyzed with Fisher test. Results: The study did not find any significant difference of average age and PR�s expression, however there were significant differences of gender proportion with PR�s expression. The study shows that 50% of meningiomas expressed progesterone reseptors with the proportion of female patients (58,3%) higher than male patients. Conclusion: In this study, there was no significant difference between PR�s expression and average ages but there was significant difference with gender in beningn orbitocranial meningiomas. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , BETHARI KUNTI ABIANTI and , dr. Agus Supartoto, Sp.M(K). (2014) PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=69093 |
| spellingShingle | ETD , BETHARI KUNTI ABIANTI , dr. Agus Supartoto, Sp.M(K). PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK |
| title | PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI
USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL
JINAK |
| title_full | PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI
USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL
JINAK |
| title_fullStr | PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI
USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL
JINAK |
| title_full_unstemmed | PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI
USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL
JINAK |
| title_short | PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI
USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL
JINAK |
| title_sort | perbedaan ekspresi reseptor progesteron pada berbagai usia dan jenis kelamin pasien meningioma orbitokranial jinak |
| topic | ETD |
| work_keys_str_mv | AT betharikuntiabianti perbedaanekspresireseptorprogesteronpadaberbagaiusiadanjeniskelaminpasienmeningiomaorbitokranialjinak AT dragussupartotospmk perbedaanekspresireseptorprogesteronpadaberbagaiusiadanjeniskelaminpasienmeningiomaorbitokranialjinak |