SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON
Synthesis of 3-hydroxy-6-methylxanthone from resorcinol and m-cresol has been conducted. Heme polymerization inhibitory activity assay of the synthesized antimalarial has also been carried out. Synthesis of antimalarial of xanthone derivative was conducted in two steps. The first step of reaction wa...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797035215529443328 |
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| author | , PRESTIKA GEMA SARI , Prof. Dr. Jumina |
| author_facet | , PRESTIKA GEMA SARI , Prof. Dr. Jumina |
| author_sort | , PRESTIKA GEMA SARI |
| collection | UGM |
| description | Synthesis of 3-hydroxy-6-methylxanthone from resorcinol and m-cresol has been conducted. Heme polymerization inhibitory activity assay of the synthesized antimalarial has also been carried out.
Synthesis of antimalarial of xanthone derivative was conducted in two steps. The first step of reaction was carboxylation of resorcinol via Kolbe reaction, resorcinol was refluxed with aqueous solution of potassium bicarbonate in the presence of carbon dioxide (CO2) then acidified by hydrogen chloride to provide 2,4-dihydroybenzoic acid compound in the form of a white solid with percent yield and melting point respectively 40.64% and 213.7�217.6 °C. The final step, carboxylation product 2,4-dihydroxybenzoic acid was reacted with m-cresol. The mixture was heated with Eaton�s reagent at 70�80 °C for 3 hours to yield 3-hydroxy-6-methylxanthone (76.7%) as a brown oily solid. The structures of products were characterized by IR, MS and 1H-NMR spectrometers.
The results of heme polymerization inhibitory activity assay of 6-hydroxy-3-methylxanthone was determined by standard curve as the reference. The results showed that 3-hydroxy-6-methylxanthone had IC50 HPIA of 8.85 � 10-3 mM, while chloroquine had IC50 0.172 mM. These results indicated that 3-hydroxy-6-methylxanthone is a potential antimalarial agent rather than chloroquine 0.172 mM |
| first_indexed | 2024-03-13T23:25:41Z |
| format | Thesis |
| id | oai:generic.eprints.org:129625 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:25:41Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1296252016-03-04T08:06:42Z https://repository.ugm.ac.id/129625/ SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON , PRESTIKA GEMA SARI , Prof. Dr. Jumina ETD Synthesis of 3-hydroxy-6-methylxanthone from resorcinol and m-cresol has been conducted. Heme polymerization inhibitory activity assay of the synthesized antimalarial has also been carried out. Synthesis of antimalarial of xanthone derivative was conducted in two steps. The first step of reaction was carboxylation of resorcinol via Kolbe reaction, resorcinol was refluxed with aqueous solution of potassium bicarbonate in the presence of carbon dioxide (CO2) then acidified by hydrogen chloride to provide 2,4-dihydroybenzoic acid compound in the form of a white solid with percent yield and melting point respectively 40.64% and 213.7�217.6 °C. The final step, carboxylation product 2,4-dihydroxybenzoic acid was reacted with m-cresol. The mixture was heated with Eaton�s reagent at 70�80 °C for 3 hours to yield 3-hydroxy-6-methylxanthone (76.7%) as a brown oily solid. The structures of products were characterized by IR, MS and 1H-NMR spectrometers. The results of heme polymerization inhibitory activity assay of 6-hydroxy-3-methylxanthone was determined by standard curve as the reference. The results showed that 3-hydroxy-6-methylxanthone had IC50 HPIA of 8.85 � 10-3 mM, while chloroquine had IC50 0.172 mM. These results indicated that 3-hydroxy-6-methylxanthone is a potential antimalarial agent rather than chloroquine 0.172 mM [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , PRESTIKA GEMA SARI and , Prof. Dr. Jumina (2014) SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70019 |
| spellingShingle | ETD , PRESTIKA GEMA SARI , Prof. Dr. Jumina SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title | SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title_full | SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title_fullStr | SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title_full_unstemmed | SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title_short | SINTESIS DAN UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEM SENYAWA 3-HIDROKSI-6-METILSANTON |
| title_sort | sintesis dan uji aktivitas penghambatan polimerisasi hem senyawa 3 hidroksi 6 metilsanton |
| topic | ETD |
| work_keys_str_mv | AT prestikagemasari sintesisdanujiaktivitaspenghambatanpolimerisasihemsenyawa3hidroksi6metilsanton AT profdrjumina sintesisdanujiaktivitaspenghambatanpolimerisasihemsenyawa3hidroksi6metilsanton |