| Summary: | BACKGROUND: Epstein Barr Virus (EBV) infects more than
90% of the world population and is classified as
oncogenic virus. EBV is associated with various
epithelial and lymphoid malignancies including
nasopharyngeal carcinoma (NPC). NPC is a rare
malignancy throughout most of the world, however a high
incidence rate of NPC is well documented in Southeast
Asia and Southern China. NPC was classified by World
Health Organization (WHO) into 3 types, where type 3 is
the most common and strongly associated with EBV
infection. Reactivation of EBV is reflected by IgA-EBV
response and can be used as specific biomarker for NPC.
High IgA-EBV is detected in NPC patients, but high IgAEBV
also detected in haelthy individual and may be a
risk factor of NPC. Smoking is known to be associated
with high levels of IgA-EBV.
OBJECTIVE: To observe the association between smoking
and IgA-EBV titres on healthy people .
METHOD: A Cross sectional design is used in this study.
279 donors at PMI Kodya Yogyakarta and Sleman was
included and given questionnaire about demographic data
and smoking habits. Blood samples were collected and
tested for IgA-EBV using indirect ELISA method.
Association between smoking habits and IgA-EBV titres was analyzed using logistic regression with and without
adjustment of age and education.
RESULT: In total, 56 subjects (20,07%) have IgA-EBV
titres above the cut-off value (0,35). Women was not
included in this analysis because of the insufficient
number of subjects. Ever smoker is associated with high
level of IgA-EBV in men (OR=2,023
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