| Summary: | Chitosan is a natural polymer and it is biodegradable polysaccharide, nontoxic,
unfold tight junction, mucoadhesive and increase drug absorbtion. Long
chains chitosan has properties that are less profitable, because of its poor
solubility in water and high viscosity. Thus, in this research, chitosan chain
scission with 150 kGy radiation dose of gamma rays. This study aims to produce
GVT-0 nanoparticles using irradiated chitosan with ionic gelation method and
tripolyphosphate as a crosslinker.
Characterization of Gamma-rays irradiated chitosan are organoleptic,
determination of its viscosity, and degree of deacetylation, meanwhile the
characterization of GVT-0 nanoparticles include particle size, particle size
distribution, morphology of nanoparticles, and entrapment efficiency.
The results showed that the irradiated chitosan has more brownish color
flake, lower viscosity (2,26 ± 0,12 cP) and higher degree of deacetylation
(65,230%) compared with non-irradiated chitosan (viscosity: 86,78 ± 4,008 cP
and a degree of deacetylation: 65,230%). Irradiated chitosan can produce GVT-0
nanoparticles that has better characteristics than non-irradiated chitosan. GVT-0
nanoparticles produced by irradiated chitosan has smaller particle size (48,967 ±
4,126 nm), more uniform particle size distribution, spherical shape, but has lower
entrapment efficiency (93,048% ± 0,033%) at the formula C2 with concentration
of GVT-0: chitosan: TPP = 0,02% - 0,04% - 0,003%, compared with GVT-0
nanoparticles produced by non-irradiated chitosan.
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