UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN
Teratogenic test of extract sample DLBS5447® (Zingiber majus) on female pregnant rats Sprague Dawley strain review of the fetal skeletal system aims to evaluate the safety extract sample DLBS5447® (Zingiber majus) when it was used on pregnant women, especially during the period of organogenesis. T...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1826048449030651904 |
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| author | , RARAS AYU KEMALASARI , Dra. Nurlaila, M. Si., Apt. |
| author_facet | , RARAS AYU KEMALASARI , Dra. Nurlaila, M. Si., Apt. |
| author_sort | , RARAS AYU KEMALASARI |
| collection | UGM |
| description | Teratogenic test of extract sample DLBS5447® (Zingiber majus) on female pregnant rats Sprague Dawley strain review of the fetal skeletal system aims to evaluate the safety extract sample DLBS5447® (Zingiber majus) when it was used on pregnant women, especially during the period of organogenesis.
The research was conducted using the rats Sprague Dawley strain of adult virgin female, healthy, weight between 175-250 grams that have estrus cycle regularly. The rats were divided into 4 groups: Group I (control) was given CMC-Na, Groups II, III, and IV were the treatment groups given extract sample DLBS5447® at a dose of 37.8 mg/kg of body weight, 75.6 mg/kg of body weight, 151.2 mg/kg of body weight.
The rats were treated orally once a day from the 1st until the 17th of pregnancy. Then on the 20th day of pregnancy, it was performed a caesarean surgery. The fetus was separated from the mother and then observed the fetal skeletal system then analyzed statistical with confidence level of 95%.
The results showed that in the group 2 doses (75,6 mg/kg BW) caused rudimentary abnormalities on the vertebrae, while in the group 3 doses (151,2 mg/kg BW) caused partially ossified abnormalities on the sternebra and increased the incidence of carpal not ossified. |
| first_indexed | 2024-03-13T23:29:44Z |
| format | Thesis |
| id | oai:generic.eprints.org:130574 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:29:44Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1305742016-03-04T08:08:18Z https://repository.ugm.ac.id/130574/ UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN , RARAS AYU KEMALASARI , Dra. Nurlaila, M. Si., Apt. ETD Teratogenic test of extract sample DLBS5447® (Zingiber majus) on female pregnant rats Sprague Dawley strain review of the fetal skeletal system aims to evaluate the safety extract sample DLBS5447® (Zingiber majus) when it was used on pregnant women, especially during the period of organogenesis. The research was conducted using the rats Sprague Dawley strain of adult virgin female, healthy, weight between 175-250 grams that have estrus cycle regularly. The rats were divided into 4 groups: Group I (control) was given CMC-Na, Groups II, III, and IV were the treatment groups given extract sample DLBS5447® at a dose of 37.8 mg/kg of body weight, 75.6 mg/kg of body weight, 151.2 mg/kg of body weight. The rats were treated orally once a day from the 1st until the 17th of pregnancy. Then on the 20th day of pregnancy, it was performed a caesarean surgery. The fetus was separated from the mother and then observed the fetal skeletal system then analyzed statistical with confidence level of 95%. The results showed that in the group 2 doses (75,6 mg/kg BW) caused rudimentary abnormalities on the vertebrae, while in the group 3 doses (151,2 mg/kg BW) caused partially ossified abnormalities on the sternebra and increased the incidence of carpal not ossified. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , RARAS AYU KEMALASARI and , Dra. Nurlaila, M. Si., Apt. (2014) UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70999 |
| spellingShingle | ETD , RARAS AYU KEMALASARI , Dra. Nurlaila, M. Si., Apt. UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title | UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title_full | UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title_fullStr | UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title_full_unstemmed | UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title_short | UJI KETERATOGENIKAN EKSTRAK SAMPEL DLBS5447 ® (Zingiber majus) PADA TIKUS BUNTING SPRAGUE DAWLEY TINJAUAN TERHADAP SISTEM SKELETAL JANIN |
| title_sort | uji keteratogenikan ekstrak sampel dlbs5447 a r zingiber majus pada tikus bunting sprague dawley tinjauan terhadap sistem skeletal janin |
| topic | ETD |
| work_keys_str_mv | AT rarasayukemalasari ujiketeratogenikanekstraksampeldlbs5447azingibermajuspadatikusbuntingspraguedawleytinjauanterhadapsistemskeletaljanin AT dranurlailamsiapt ujiketeratogenikanekstraksampeldlbs5447azingibermajuspadatikusbuntingspraguedawleytinjauanterhadapsistemskeletaljanin |