PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI
Ketoprofen is one of most commonly used drug in Indonesia as an antiinflammatory drug for rheumatoid arthritis and osteoarthritis treatment. Ketoprofen has low solubility in gastric fluid provide by low pKa (±4.00). In which dissolution of the drug is the rate limiting step of absorption, ketoprofe...
| Main Authors: | , |
|---|---|
| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
|
| Subjects: |
| _version_ | 1826048472422285312 |
|---|---|
| author | , KARINNA ASRI YULIETYANI ZEIN , Dr.rer.nat. Ronny Martien, M.Si. |
| author_facet | , KARINNA ASRI YULIETYANI ZEIN , Dr.rer.nat. Ronny Martien, M.Si. |
| author_sort | , KARINNA ASRI YULIETYANI ZEIN |
| collection | UGM |
| description | Ketoprofen is one of most commonly used drug in Indonesia as an antiinflammatory
drug for rheumatoid arthritis and osteoarthritis treatment.
Ketoprofen has low solubility in gastric fluid provide by low pKa (±4.00). In
which dissolution of the drug is the rate limiting step of absorption, ketoprofen
was formulated to nanoemulsion by SNEDDS (Self-Nanoemulsifying Drug
Delivery System) method. As drug delivery system, SNEDDS has some
limitations such as high production cost and too hard to manufacture. So that, SSNEDDS
(Solid Self-Nanoemulsifying Drug delivery System) was developed as
the one of promising solution. This aim of study is to formulate SNEDDS by
VCO (Virgin Coconut Oil) as oil phase, Tween 80 as surfactant, PEG 400 as cosurfactant,
and Aerosil as solidifying agent.
Ketoprofen nanoemulsion with 0.833 ml VCO, 3.565 ml Tween 80, 0.605
ml PEG 400, and 50 mg/ml ketoprofen gave the best result as selected formula.
Droplet size of nanoemulsion is 2.7 ± 0.8 nm with PI (Polidispersity Index) 0.402.
Nanoemulsion ketoprofen gave emulsification time 44.43 ± 0.232 s in artificial
gastric fluid (AGF) and 46.57 ± 0.193 s in artificial intestinal fluid at 37°C. Result
of stabilization study claimed that ketoprofen nanoemulsion could stand within a
week in 2 media (AGF and AIF). S-SNEDDS ketoprofen was formulated by spray
drying and modification of fluid bed granulator methods with aerosol and clarity
of nanoemulsion was obtained by ultraviolet spectrophotometry at 650 nm. Spray
drying method could formulate ketoprofen nanoemulsion with 69.23 ± 0.115 %
clarity and 48.956 % drug content. Beside, modification of fluid bed granulator
gave the best result, 93.23 ± 1.361 % in clarity and 49.981% in drug content. |
| first_indexed | 2024-03-13T23:30:07Z |
| format | Thesis |
| id | oai:generic.eprints.org:130691 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:30:07Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1306912016-03-04T07:57:53Z https://repository.ugm.ac.id/130691/ PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI , KARINNA ASRI YULIETYANI ZEIN , Dr.rer.nat. Ronny Martien, M.Si. ETD Ketoprofen is one of most commonly used drug in Indonesia as an antiinflammatory drug for rheumatoid arthritis and osteoarthritis treatment. Ketoprofen has low solubility in gastric fluid provide by low pKa (±4.00). In which dissolution of the drug is the rate limiting step of absorption, ketoprofen was formulated to nanoemulsion by SNEDDS (Self-Nanoemulsifying Drug Delivery System) method. As drug delivery system, SNEDDS has some limitations such as high production cost and too hard to manufacture. So that, SSNEDDS (Solid Self-Nanoemulsifying Drug delivery System) was developed as the one of promising solution. This aim of study is to formulate SNEDDS by VCO (Virgin Coconut Oil) as oil phase, Tween 80 as surfactant, PEG 400 as cosurfactant, and Aerosil as solidifying agent. Ketoprofen nanoemulsion with 0.833 ml VCO, 3.565 ml Tween 80, 0.605 ml PEG 400, and 50 mg/ml ketoprofen gave the best result as selected formula. Droplet size of nanoemulsion is 2.7 ± 0.8 nm with PI (Polidispersity Index) 0.402. Nanoemulsion ketoprofen gave emulsification time 44.43 ± 0.232 s in artificial gastric fluid (AGF) and 46.57 ± 0.193 s in artificial intestinal fluid at 37°C. Result of stabilization study claimed that ketoprofen nanoemulsion could stand within a week in 2 media (AGF and AIF). S-SNEDDS ketoprofen was formulated by spray drying and modification of fluid bed granulator methods with aerosol and clarity of nanoemulsion was obtained by ultraviolet spectrophotometry at 650 nm. Spray drying method could formulate ketoprofen nanoemulsion with 69.23 ± 0.115 % clarity and 48.956 % drug content. Beside, modification of fluid bed granulator gave the best result, 93.23 ± 1.361 % in clarity and 49.981% in drug content. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , KARINNA ASRI YULIETYANI ZEIN and , Dr.rer.nat. Ronny Martien, M.Si. (2014) PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71118 |
| spellingShingle | ETD , KARINNA ASRI YULIETYANI ZEIN , Dr.rer.nat. Ronny Martien, M.Si. PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title | PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title_full | PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title_fullStr | PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title_full_unstemmed | PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title_short | PEMBUATAN S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) KETOPROFEN MENGGUNAKAN MINYAK NABATI |
| title_sort | pembuatan s snedds solid self nanoemulsifying drug delivery system ketoprofen menggunakan minyak nabati |
| topic | ETD |
| work_keys_str_mv | AT karinnaasriyulietyanizein pembuatanssneddssolidselfnanoemulsifyingdrugdeliverysystemketoprofenmenggunakanminyaknabati AT drrernatronnymartienmsi pembuatanssneddssolidselfnanoemulsifyingdrugdeliverysystemketoprofenmenggunakanminyaknabati |