EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA
Epilepsy is a neurological condition characterized by recurrent seizures recurrence. Most cases of epilepsy in children at age 1-6 years (46,5%), 6-10 years (29,1%), 10-18 years (16,28%) and 0-1 years (8,14%).The high prevalence of epilepsy children can lead to many use of antiepileptic drugs, is...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| author | , Masita Wulandari S , Prof. Dr. Djoko Wahyono, SU., Apt |
| author_facet | , Masita Wulandari S , Prof. Dr. Djoko Wahyono, SU., Apt |
| author_sort | , Masita Wulandari S |
| collection | UGM |
| description | Epilepsy is a neurological condition characterized by recurrent seizures
recurrence. Most cases of epilepsy in children at age 1-6 years (46,5%), 6-10
years (29,1%), 10-18 years (16,28%) and 0-1 years (8,14%).The high prevalence
of epilepsy children can lead to many use of antiepileptic drugs, is one of the
antiepileptic drug valproic acid. Valproic acid is a drug with a narrow therapeutic
index therapeutic range of 50-100 mg/L. The use of children aged < 2 years are at
greater risk of toxic to the pancreas and liver. That requires monitoring and dose
adjustments to prevent toxic effects.
Monitoring TDM (Therapeutic Drug Monitoring) can be done through a
review of pharmacokinetics to estimate the therapeutic dose levels of the drug by
the patient. So known drug levels in the blood and associatedwith therapeutic
results obtained.
This study is a retrospective study with a descriptive analysis of the
observational design. Research subject is a child epilepsy patients with valproic
acid monotherapy period January 2009 - December 2013 aged 2-14 years, men
and women who are hospitalized. The results observed therapy is seizure-free
duration (< 6 months and �6 months).
The results of this study were 24 patients (48%) corresponding to the
therapeutic range (50-100 mg/L) and 26 patients (52%) were not in accordance
with the therapeutic range (<50 mg/L or >100 mg/L). Clinical outcomes was
assessed based on the duration of seizure free patients showed 37 patients (74%)
gave good outcome and 13 patients (26%) gave a por outcome. |
| first_indexed | 2024-03-13T23:31:36Z |
| format | Thesis |
| id | oai:generic.eprints.org:130972 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:31:36Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1309722016-03-04T08:02:00Z https://repository.ugm.ac.id/130972/ EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA , Masita Wulandari S , Prof. Dr. Djoko Wahyono, SU., Apt ETD Epilepsy is a neurological condition characterized by recurrent seizures recurrence. Most cases of epilepsy in children at age 1-6 years (46,5%), 6-10 years (29,1%), 10-18 years (16,28%) and 0-1 years (8,14%).The high prevalence of epilepsy children can lead to many use of antiepileptic drugs, is one of the antiepileptic drug valproic acid. Valproic acid is a drug with a narrow therapeutic index therapeutic range of 50-100 mg/L. The use of children aged < 2 years are at greater risk of toxic to the pancreas and liver. That requires monitoring and dose adjustments to prevent toxic effects. Monitoring TDM (Therapeutic Drug Monitoring) can be done through a review of pharmacokinetics to estimate the therapeutic dose levels of the drug by the patient. So known drug levels in the blood and associatedwith therapeutic results obtained. This study is a retrospective study with a descriptive analysis of the observational design. Research subject is a child epilepsy patients with valproic acid monotherapy period January 2009 - December 2013 aged 2-14 years, men and women who are hospitalized. The results observed therapy is seizure-free duration (< 6 months and �6 months). The results of this study were 24 patients (48%) corresponding to the therapeutic range (50-100 mg/L) and 26 patients (52%) were not in accordance with the therapeutic range (<50 mg/L or >100 mg/L). Clinical outcomes was assessed based on the duration of seizure free patients showed 37 patients (74%) gave good outcome and 13 patients (26%) gave a por outcome. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Masita Wulandari S and , Prof. Dr. Djoko Wahyono, SU., Apt (2014) EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71406 |
| spellingShingle | ETD , Masita Wulandari S , Prof. Dr. Djoko Wahyono, SU., Apt EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title | EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title_full | EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title_fullStr | EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title_full_unstemmed | EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title_short | EVALUASI DOSIS ASAM VALPROAT PADA PASIEN EPILEPSI ANAK DI BANGSAL RAWAT INAP ANAK RSUP DR. SARDJITO YOGYAKARTA |
| title_sort | evaluasi dosis asam valproat pada pasien epilepsi anak di bangsal rawat inap anak rsup dr sardjito yogyakarta |
| topic | ETD |
| work_keys_str_mv | AT masitawulandaris evaluasidosisasamvalproatpadapasienepilepsianakdibangsalrawatinapanakrsupdrsardjitoyogyakarta AT profdrdjokowahyonosuapt evaluasidosisasamvalproatpadapasienepilepsianakdibangsalrawatinapanakrsupdrsardjitoyogyakarta |