KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG�
Diet with high lipids cause hyperlipidemia. Hyperlipidemia stimulate leukocytes to produce ROS (Reactive Oxygen Species) thereby increasing LDL oxidation. Macrophages phagocytosis oxidized-LDL and form plaque. Black rice has high fiber and anthocyanin, which act as antioxidants and can repair the hy...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797035494876381184 |
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| author | , NOOR NAILIS SAADAH , Dr. Rarastoeti Pratiwi, M.Sc., Ph.D. |
| author_facet | , NOOR NAILIS SAADAH , Dr. Rarastoeti Pratiwi, M.Sc., Ph.D. |
| author_sort | , NOOR NAILIS SAADAH |
| collection | UGM |
| description | Diet with high lipids cause hyperlipidemia. Hyperlipidemia stimulate
leukocytes to produce ROS (Reactive Oxygen Species) thereby increasing LDL
oxidation. Macrophages phagocytosis oxidized-LDL and form plaque. Black rice
has high fiber and anthocyanin, which act as antioxidants and can repair the
hyperlipidemia condition. The purpose of this study was to determine the content
of ROS, Apo B-100, and atherogenic index of hyperlipidemic Wistar rats (Rattus
norvegicus Berkenhout, 1769) which consumed rice and bran of black rice (O.
sativa L.) �Cempo Ireng�. The research had done with pre and post test
randomized control group design. Rats had given a mixture of lard and duck egg
yolk (1:1), and pure cholesterol (2% of total volume) orally as much as 1% of
body weight (BW) for 30 days. After hyperlipidemia achieved, rats divided into 4
group: normal rats, hyperlipidemic rats, hyperlipidemic rats fed a diet of 30%
black rice pellet, and hyperlipidemic rats fed a diet of 10% black rice bran. Blood
samples were collected when rats in hyperlipidemia conditions and after treatment
with black rice for 30 days. Data of total cholesterol and HDL-Cholesterol level,
atherogenic index, ROS, and Apo B-100 level analyzed using ANOVA followed
by Tukey test at 5% significance level. The result showed that feeding pellet of
rice and bran of black rice \"Cempo Ireng\" in hyperlipidemic rats provide
unsignificant difference (p>0.05) on the contents of ROS and Apo B-100 blood
serum, but decreased total cholesterol and increased of HDL-cholesterol levels
significantly (p<0.05), so the atherogenic index also decreased significantly.
Decreasing atherogenic index of hyperlipidemic rats which fed black rice bran
pellets is higher than rats which fed black rice \"Cempo Ireng\" pellets. Total
cholesterol levels were positively correlated with the atherogenic index, whereas
HDL-cholesterol was negatively correlated with the atherogenic index. On the
other side, the levels of ROS and Apo B-100 were less associated with
atherogenic index.
Key words : Hyperlipidemia, Atherogenic index, ROS, Apo B-100, Black rice
�Cempo Ireng� |
| first_indexed | 2024-03-13T23:31:43Z |
| format | Thesis |
| id | oai:generic.eprints.org:131008 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:31:43Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1310082016-03-04T08:03:45Z https://repository.ugm.ac.id/131008/ KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� , NOOR NAILIS SAADAH , Dr. Rarastoeti Pratiwi, M.Sc., Ph.D. ETD Diet with high lipids cause hyperlipidemia. Hyperlipidemia stimulate leukocytes to produce ROS (Reactive Oxygen Species) thereby increasing LDL oxidation. Macrophages phagocytosis oxidized-LDL and form plaque. Black rice has high fiber and anthocyanin, which act as antioxidants and can repair the hyperlipidemia condition. The purpose of this study was to determine the content of ROS, Apo B-100, and atherogenic index of hyperlipidemic Wistar rats (Rattus norvegicus Berkenhout, 1769) which consumed rice and bran of black rice (O. sativa L.) �Cempo Ireng�. The research had done with pre and post test randomized control group design. Rats had given a mixture of lard and duck egg yolk (1:1), and pure cholesterol (2% of total volume) orally as much as 1% of body weight (BW) for 30 days. After hyperlipidemia achieved, rats divided into 4 group: normal rats, hyperlipidemic rats, hyperlipidemic rats fed a diet of 30% black rice pellet, and hyperlipidemic rats fed a diet of 10% black rice bran. Blood samples were collected when rats in hyperlipidemia conditions and after treatment with black rice for 30 days. Data of total cholesterol and HDL-Cholesterol level, atherogenic index, ROS, and Apo B-100 level analyzed using ANOVA followed by Tukey test at 5% significance level. The result showed that feeding pellet of rice and bran of black rice \"Cempo Ireng\" in hyperlipidemic rats provide unsignificant difference (p>0.05) on the contents of ROS and Apo B-100 blood serum, but decreased total cholesterol and increased of HDL-cholesterol levels significantly (p<0.05), so the atherogenic index also decreased significantly. Decreasing atherogenic index of hyperlipidemic rats which fed black rice bran pellets is higher than rats which fed black rice \"Cempo Ireng\" pellets. Total cholesterol levels were positively correlated with the atherogenic index, whereas HDL-cholesterol was negatively correlated with the atherogenic index. On the other side, the levels of ROS and Apo B-100 were less associated with atherogenic index. Key words : Hyperlipidemia, Atherogenic index, ROS, Apo B-100, Black rice �Cempo Ireng� [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , NOOR NAILIS SAADAH and , Dr. Rarastoeti Pratiwi, M.Sc., Ph.D. (2014) KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG�. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71444 |
| spellingShingle | ETD , NOOR NAILIS SAADAH , Dr. Rarastoeti Pratiwi, M.Sc., Ph.D. KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title | KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title_full | KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title_fullStr | KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title_full_unstemmed | KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title_short | KANDUNGAN ROS DAN Apo B-100 SERUM, SERTA INDEKS ATEROGENIK TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769) HIPERLIPIDEMIA DENGAN ASUPAN PELET NASI DAN BEKATUL BERAS HITAM (Oryza sativa L.) �CEMPO IRENG� |
| title_sort | kandungan ros dan apo b 100 serum serta indeks aterogenik tikus putih rattus norvegicus berkenhout 1769 hiperlipidemia dengan asupan pelet nasi dan bekatul beras hitam oryza sativa l a��cempo irenga�� |
| topic | ETD |
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