| Summary: | Gingiva is a part of oral mucosa which injury often occured. Macrophages is
inflammatory cells which function to phagocytes and produce important cytokines.
Guava leaves (Psidium guajava Linn.) contains flavonoids that can accelerate the
wound healing process. The aim of this study was to determine the effect of topical
application g uava leaf�s (Psidium guajava Linn.) extract gel on the number of
macrophages in the wound healing process of gingival (in-vivo studies on Sprague
dawley).
Twenty seven male Sprague dawley were divided into three groups, each 9
rats in treatment group (Psidium guajava leaf extract gel), positive control group
(Aloclair� gel), and negative con trol group (CMC-Na 2%). Each rats were given
injury at the lower centralis incisor labial gingival using a 2,5 mm diameter of punch
biopsy. Topical application given to each group for 7 days with frequency of 2 times
a day, after that the rat�s injur y tissue w ere decapitated to made histological samples
using Hematoxylin Eosin staining. Number of macrophages in wound area was
counted under a light microscope 400 times magnification in 6 fields of view.
The result of this research on day-3, 5 and 7 showed that was a significant
differences in the number of macrophage between guava leaf extract gel groups, and
Alocla ir� gel groups with CMC-Na groups, meanwhile there were no significant
differences between g uava leaf extract gel and A locla ir� gel. The conclusion of this
research was the application of guava leaves (Psidium guajava Linn.) extract gel can
reduce the number of macrophages in the wound healing process of gingival (in-vivo
studies on Sprague dawley).
Keywords : Psidium guajava Linn., Wound Healing, Macrophage
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