| Summary: | Ibuprofen is a nonsteroid anti-inflammatory drug (NSAID) that can inhibit activities
of siklooksigenase-1 and siklooksigenase-2 isoenzyme, so thats with inhibiting the changing
of arachidonic acid to prostaglandin can be decreased. Ibuprofen belongs to BCS class II,
because it has high permeability and low solubility. The goals of this research are to
determine the pKa of ibuprofen and to know the influence of the complexe formation of
ibuprofen with β-cyclodextrin on ibuprofen solubility.
Determinnation of the pKa value of ibuprofen has been conducted by measuring
absorbance at wavelength 266 nm. The optimization of complexes formation has been
worked using factorial design method. Than, the complexes of ibuprofen and β-cyclodextrin
evaluated using infrared spectrophotometry, and optimized with using software design
expert version: 7.1.3.
The result of this research showeds that the pKa value of ibuprofen wasis 4, 37 ±
0,07 and 5, 24 ± 0,07. The complexes ibuprofen with β--siklodekstrin was evaluated using
infrared spectrophotometry there was no peak at 1721 cm-1 that indicated that there was no
functional group of �C=O. Based on simplex lattice design calculation, the best complexes
consisted of ibuprofen and β-cyclodextrin in ratio120 and 180. The solubilitydata showed
that complexes of ibuprofen with β-cyclodextrin was2,30 ± 0,12 timesat pH 1,30 ± 0,16
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