OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN
Transdermal delivery system is possible to transport PGV-0. This study was aimed 1) to formulate PGV-0 transdermal matrix with optimal physicochemical characteristics and release rate, 2) to establish the in vitro transport profile of transdermal PGV-0 across the skin. The combination of PVP and met...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2014
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| _version_ | 1797035917161005056 |
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| author | , Metha Anung A , Dr. Akhmad Kharis Nugroho,M.Si., Apt. |
| author_facet | , Metha Anung A , Dr. Akhmad Kharis Nugroho,M.Si., Apt. |
| author_sort | , Metha Anung A |
| collection | UGM |
| description | Transdermal delivery system is possible to transport PGV-0. This study was aimed 1) to formulate PGV-0 transdermal matrix with optimal physicochemical characteristics and release rate, 2) to establish the in vitro transport profile of transdermal PGV-0 across the skin.
The combination of PVP and methylcellulose in transdermal matrix of PGV-0 was determined by Design Expert 7.1.5. The physicocemical characteristics consist of weight, thickness, % moisture content, % moisture uptake, folding endurance, and drug content were evaluated. PGV-0 release rate was tested using Millipore membrane in a vertical diffusion cells for 6 hours. Optimization of the matrix formula was performed based on the significant responses. Transdermal transport study was carried out on optimal formula using vertical diffusion cell and full-thickness rat skin for 24 hours.
The entire formulas could produce uniform and flexible transdermal matrices. The combination of PVP and methylcellulose had a significant influence on the weight, thickness, drug content, and dissolution efficiency of PGV-0 transdermal matrix. The combination of 2.436 % PVP and 1.564 % methylcellulose as an optimal formula produces light yellow, flat, and flexible PGV-0 transdermal matrix. The optimal matrix had weight of 0.304 g, thickness of 0.378 mm, drug content of 101.37 %, and dissolution efficiency of 21.33%. The release results of optimal matrix was analyzed using compartement model method. The data results indicates that the release profile of PGV-0 from transdermal matrix follow 4 compartements model with 2 compartements lag. The optimal formula of transdermal matrix could not transport PGV-0 across the skin. |
| first_indexed | 2024-03-13T23:37:59Z |
| format | Thesis |
| id | oai:generic.eprints.org:133014 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T23:37:59Z |
| publishDate | 2014 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1330142016-03-04T08:02:10Z https://repository.ugm.ac.id/133014/ OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN , Metha Anung A , Dr. Akhmad Kharis Nugroho,M.Si., Apt. ETD Transdermal delivery system is possible to transport PGV-0. This study was aimed 1) to formulate PGV-0 transdermal matrix with optimal physicochemical characteristics and release rate, 2) to establish the in vitro transport profile of transdermal PGV-0 across the skin. The combination of PVP and methylcellulose in transdermal matrix of PGV-0 was determined by Design Expert 7.1.5. The physicocemical characteristics consist of weight, thickness, % moisture content, % moisture uptake, folding endurance, and drug content were evaluated. PGV-0 release rate was tested using Millipore membrane in a vertical diffusion cells for 6 hours. Optimization of the matrix formula was performed based on the significant responses. Transdermal transport study was carried out on optimal formula using vertical diffusion cell and full-thickness rat skin for 24 hours. The entire formulas could produce uniform and flexible transdermal matrices. The combination of PVP and methylcellulose had a significant influence on the weight, thickness, drug content, and dissolution efficiency of PGV-0 transdermal matrix. The combination of 2.436 % PVP and 1.564 % methylcellulose as an optimal formula produces light yellow, flat, and flexible PGV-0 transdermal matrix. The optimal matrix had weight of 0.304 g, thickness of 0.378 mm, drug content of 101.37 %, and dissolution efficiency of 21.33%. The release results of optimal matrix was analyzed using compartement model method. The data results indicates that the release profile of PGV-0 from transdermal matrix follow 4 compartements model with 2 compartements lag. The optimal formula of transdermal matrix could not transport PGV-0 across the skin. [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Metha Anung A and , Dr. Akhmad Kharis Nugroho,M.Si., Apt. (2014) OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73560 |
| spellingShingle | ETD , Metha Anung A , Dr. Akhmad Kharis Nugroho,M.Si., Apt. OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title | OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title_full | OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title_fullStr | OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title_full_unstemmed | OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title_short | OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN |
| title_sort | optimasi formula matriks transdermal pentagamavunon 0 dengan kombinasi polimer pvp dan metilselulosa menggunakan simplex lattice design |
| topic | ETD |
| work_keys_str_mv | AT methaanunga optimasiformulamatrikstransdermalpentagamavunon0dengankombinasipolimerpvpdanmetilselulosamenggunakansimplexlatticedesign AT drakhmadkharisnugrohomsiapt optimasiformulamatrikstransdermalpentagamavunon0dengankombinasipolimerpvpdanmetilselulosamenggunakansimplexlatticedesign |